Gene interactions and pathways from curated databases and text-mining
J Biol Chem 2011, PMID: 21778237

COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.

Mao, Xicheng; Gluck, Nathan; Chen, Baozhi; Starokadomskyy, Petro; Li, Haiying; Maine, Gabriel N; Burstein, Ezra

Cullin RING ligases (CRLs), the most prolific class of ubiquitin ligase enzymes, are multimeric complexes that regulate a wide range of cellular processes. CRL activity is regulated by CAND1 (Cullin-associated Nedd8-dissociated protein 1), an inhibitor that promotes the dissociation of substrate receptor components from the CRL. We demonstrate here that COMMD1 (copper metabolism MURR1 domain-containing 1), a factor previously found to promote ubiquitination of various substrates, regulates CRL activation by antagonizing CAND1 binding. We show that COMMD1 interacts with multiple Cullins, that the COMMD1-Cul2 complex cannot bind CAND1, and that, conversely, COMMD1 can actively displace CAND1 from CRLs. These findings highlight a novel mechanism of CRL activation and suggest that CRL regulation may underlie the pleiotropic activities of COMMD1.

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Text Mining Data

COMMD1 — CAND1: " COMMD1 ( copper metabolism MURR1 domain containing protein 1 ) regulates Cullin RING ligases by preventing CAND1 ( Cullin associated Nedd8 dissociated protein 1 ) binding "

Manually curated Databases

  • IRef Biogrid Interaction: CUL1 — COMMD1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CUL1 — COMMD1 (direct interaction, pull down)
  • IRef Biogrid Interaction: CAND1 — CUL1 (direct interaction, pull down)
  • IRef Biogrid Interaction: COMMD1 — CUL3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: COMMD1 — CUL3 (direct interaction, pull down)
  • IRef Biogrid Interaction: CUL7 — COMMD1 (direct interaction, pull down)
  • IRef Biogrid Interaction: CAND1 — CUL2 (direct interaction, pull down)
  • IRef Biogrid Interaction: CUL1 — SKP1 (direct interaction, pull down)
  • IRef Biogrid Interaction: CUL2 — RBX1 (direct interaction, pull down)
  • IRef Biogrid Interaction: COMMD1 — CUL4A (direct interaction, pull down)
  • IRef Biogrid Interaction: COMMD1 — CUL2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: COMMD1 — CUL2 (direct interaction, pull down)
  • IRef Biogrid Interaction: COMMD1 — CUL2 (association, biochemical)
  • IRef Biogrid Interaction: COMMD1 — CUL4B (direct interaction, pull down)
  • IRef Biogrid Interaction: CUL1 — CUL1 (direct interaction, pull down)
  • IRef Biogrid Interaction: COMMD1 — CUL5 (direct interaction, pull down)
In total, 12 gene pairs are associated to this article in curated databases