We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
Eur J Pediatr 1987, PMID: 2884108

Circulating somatomedin-C levels and the effect of growth hormone-releasing factor on plasma levels of growth hormone and somatostatin-like immunoreactivity in obese children.

Rosskamp, R; Becker, M; Soetadji, S

The effect of growth hormone-releasing factor (GRF) 1-44 on growth hormone and somatostatin release in plasma has been studied in 20 obese children. Twenty age and sex-matched children with normal weight served as controls. Mean peak growth hormone response in obese children after 1 microgram/kg body wt. GRF 1-44 was significantly lower than in controls (23.7 +/- 3.6 ng/ml vs. 41.1 +/- 3.0 ng/ml; P less than 0.01), as were mean integrated growth hormone response areas (1544 +/- 272 ng X ml-1 X 2 h vs. 2476 +/- 283 ng X ml-1 X 2 h; P less than 0.01). Mean plasma levels of somatostatin-like immunoreactivity did not change after GRF in both groups. Mean somatomedin-C levels in obese children were significantly higher compared to controls (1.6 +/- 0.4 U/ml vs. 0.86 +/- 0.4 U/ml; P less than 0.01). Somatomedin-C levels were not related to the integrated growth hormone responses. In conclusion there is no relation between somatomedin-C levels and the reduced growth hormone-releasing effect of GRF in obese children. GRF does not alter peripheral somatostatin-like immunoreactivity levels either in normal or obese children.

Diseases/Pathways annotated by Medline MESH: Obesity
Document information provided by NCBI PubMed

Text Mining Data

somatostatin-like — growth hormone releasing factor: " Circulating somatomedin-C levels and the effect of growth hormone releasing factor on plasma levels of growth hormone and somatostatin-like immunoreactivity in obese children "

somatostatin-like — somatomedin-C: " Circulating somatomedin-C levels and the effect of growth hormone releasing factor on plasma levels of growth hormone and somatostatin-like immunoreactivity in obese children "

growth hormone — growth hormone releasing factor: " Circulating somatomedin-C levels and the effect of growth hormone releasing factor on plasma levels of growth hormone and somatostatin-like immunoreactivity in obese children "

growth hormone — somatomedin-C: " Circulating somatomedin-C levels and the effect of growth hormone releasing factor on plasma levels of growth hormone and somatostatin-like immunoreactivity in obese children "

somatostatin — growth hormone releasing factor (GRF): " The effect of growth hormone releasing factor (GRF) 1-44 on growth hormone and somatostatin release in plasma has been studied in 20 obese children "

somatostatin — (GRF) 1-44: " The effect of growth hormone releasing factor (GRF) 1-44 on growth hormone and somatostatin release in plasma has been studied in 20 obese children "

growth hormone — growth hormone releasing factor (GRF): " The effect of growth hormone releasing factor (GRF) 1-44 on growth hormone and somatostatin release in plasma has been studied in 20 obese children "

growth hormone — (GRF) 1-44: " The effect of growth hormone releasing factor (GRF) 1-44 on growth hormone and somatostatin release in plasma has been studied in 20 obese children "

Manually curated Databases

No curated data.