Gene interactions and pathways from curated databases and text-mining
Immunology 1987, PMID: 3034768

Interferon-alpha enhances the production of leukotriene B4 in murine peritoneal macrophages stimulated by opsonized zymosan.

Ito, M; Ishida, E; Tanabe, F; Shigeta, S; Watanabe, Y; Kawade, Y

Murine peritoneal macrophages pretreated with interferon (IFN)-alpha and then stimulated by opsonized zymosan produced two to three times more LTB4 than untreated macrophages. However, PGE2 production was not changed by IFN-alpha. Meanwhile, IFN-gamma did not affect the production of LTB4 and PGE2. From the results it is considered that IFN-alpha can modulate inflammation or host defence through the production of LTB4.

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Text Mining Data

LTB4 — IFN-gamma: " Meanwhile, IFN-gamma did not affect the production of LTB4 and PGE2 "

Manually curated Databases

No curated data.