Gene interactions and pathways from curated databases and text-mining
CASP8: top 25 interacting genes (chr2:202125258-202152432)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only CASP8-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with CASP8, not among the Top 25
Other genes interacting with CASP8. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

AKT3 ▸ XIAP ▸ IL1B ▸ FASLG ▸ DIABLO ▸ MAPK3 ▸ IL1A ▸
BCL3 ▸ BCL6 ▸ BCL9 ▸ BCL5 ▸ EPHB2 ▸ MAPK1 ▸ IRF6 ▸
MAPK14 ▸ MAPK15 ▸ MAPK11 ▸ MAPK4 ▸ MAPK8 ▸ MAPK6 ▸ MAPK7 ▸
MAPK12 ▸ MAPK10 ▸ MAPK13 ▸ MAPK9 ▸ IFNG ▸ CASP3 ▸ APAF1 ▸
CAPN1 ▸ CAPN10 ▸ CAPN2 ▸ CAPN13 ▸ IL18 ▸ CAPN9 ▸ CAPN12 ▸
FADD ▸ CAPN11 ▸ CAPN3 ▸ CAPN7 ▸ CAPN15 ▸ CAPN14 ▸ CAPN8 ▸
CAPN5 ▸ CAPN6 ▸ STS ▸ ASIP ▸ DNTT ▸ MCL1 ▸ MMP9 ▸
MMP2 ▸ MMP14 ▸ MMP12 ▸ MMP11 ▸ MMP3 ▸ MMP24 ▸ MMP17 ▸
MMP15 ▸ MMP19 ▸ MMP13 ▸ NLRP3 ▸ MMP25 ▸ MMP1 ▸ CDKN1A ▸
MMP8 ▸ MMP27 ▸ MMP7 ▸ MMP28 ▸ MMP16 ▸ MMP10 ▸ MMP26 ▸
MMP21 ▸ MMP20 ▸ CASP9 ▸ JUN ▸ PDCD5 ▸ PDCD11 ▸ CASP12 ▸
RNF19A ▸ CFLAR ▸ PDCD4 ▸ PDCD1 ▸ PDCD7 ▸ PDCD6 ▸ PDCD2 ▸
PDCD10 ▸ CYCS ▸ NA ▸ CASP1 ▸ IGF1 ▸ ANXA5 ▸ CASP2 ▸
PCBD1 ▸ INS ▸ AHSA1 ▸ TGFB1 ▸ CASP6 ▸ HLA-DRB1 ▸ MPZ ▸
PI3 ▸ CASP7 ▸ NLRC4 ▸ CASP4 ▸ PIK3R1 ▸ CASP5 ▸ PIK3CA ▸
CASP14 ▸ CASP10 ▸ EPO ▸ CASP16 ▸ TNFRSF1A ▸ PRKCD ▸ DDIT3 ▸
TAT ▸ PRDX2 ▸ DISC2 ▸ DISC1 ▸ DFFA ▸ NOS2 ▸ IL6 ▸
GRAP2 ▸ GSK3B ▸ MYLIP ▸ PCNA ▸ CRK ▸ IL4 ▸ BIRC2 ▸
CTSB ▸ EGF ▸ EIF2AK2 ▸ SOD1 ▸ IL8 ▸ NOS1 ▸ CAST ▸
VEGFA ▸ CTNNB1 ▸ IRF1 ▸ NGF ▸ DFFB ▸ PAK2 ▸ PTGS2 ▸
BID ▸ LEP ▸ ROCK1 ▸ ALPI ▸ HGF ▸ DNASE1 ▸ P2RX7 ▸
APP ▸ DNASE2 ▸ ABL1 ▸ SOD2 ▸ MAP3K1 ▸ BDNF ▸ CDK2 ▸
IFNB1 ▸ TCF4 ▸ CAT ▸ MYC ▸ IL16 ▸ IFI27 ▸ BCR ▸
FOS ▸ RIPK1 ▸ APEH ▸ CSF2 ▸ CA2 ▸ NOS3 ▸ NOX1 ▸
TCF21 ▸ TCF15 ▸ TLR2 ▸ TCF7 ▸ TCF25 ▸ NFKBIA ▸ TCF3 ▸
UPK3B ▸ IL2 ▸ HTRA2 ▸ IL10 ▸ TCF19 ▸ HDAC2 ▸ NOD2 ▸
RAC1 ▸ BMP1 ▸ TCF23 ▸ TCF20 ▸ TCF12 ▸ CTSD ▸ MAP2K1 ▸
TCF24 ▸ BIRC7 ▸ FGF2 ▸ MAGT1 ▸ HDAC1 ▸ TLR3 ▸ APOB ▸
NLRP1 ▸ BMP4 ▸ GAL ▸ CD8A ▸ BAD ▸ AIM2 ▸ SOD3 ▸
STAT1 ▸ ITIH4 ▸ ATP5O ▸ HSPA5 ▸ ADCYAP1 ▸ TLR4 ▸ CDC73 ▸
LMNB1 ▸ POLDIP2 ▸ CSF3 ▸ NOX4 ▸ BIRC3 ▸ PRKDC ▸ ARSK ▸
LEO1 ▸ RB1 ▸ IL11 ▸ CD79A ▸ PPP2R2B ▸ NOD1 ▸ HMGB1 ▸
IL5 ▸ BMP10 ▸ HSPB1 ▸ PDLIM7 ▸ CARD8 ▸ TLR5 ▸ WDR61 ▸
PPP2R1A ▸ PAF1 ▸ BMP2 ▸ IL15 ▸ PPP2CA ▸ BMP5 ▸ IL3 ▸
BMP15 ▸ MST1 ▸ CDK5 ▸ RIPK2 ▸ IL33 ▸ NOX5 ▸ CTR9 ▸
PML ▸ ENDOG ▸ GZMB ▸ BMP6 ▸ STAT3 ▸ SMPD2 ▸ HPR ▸
NOX3 ▸ BMP7 ▸ KRT18 ▸ SNAP25 ▸ AGTR1 ▸ BMP3 ▸ TRAF6 ▸
TLR7 ▸ WAS ▸ RIPK3 ▸ MET ▸ CDC6 ▸ SYK ▸ LMNB2 ▸
TNFRSF1B ▸ ANXA1 ▸ HTT ▸ RBBP4 ▸ EGFR ▸ PPARA ▸ PLCG1 ▸
TXN ▸ RAD51 ▸ APC ▸ LPA ▸ PGP ▸ CREB3 ▸ CDH1 ▸
GP6 ▸ CD4 ▸ CXCL9 ▸ TLR1 ▸ IL20 ▸ CREB1 ▸ CSE ▸
IL21 ▸ CCDC88A ▸ NPS ▸ TLR10 ▸ EIF2S1 ▸ IGF2 ▸ RBBP7 ▸
GP2 ▸ HIF1A ▸ PTX4 ▸ BOC ▸ PRNP ▸ TLR8 ▸ BIRC6 ▸
GSN ▸ PTX3 ▸ GP5 ▸ CREB5 ▸ GP9 ▸ IL24 ▸ MAP2K2 ▸
ICAM1 ▸ JAK2 ▸ TRAF1 ▸ BRCA1 ▸ RAF1 ▸ MEFV ▸ RENBP ▸
MUC19 ▸ PPARG ▸ TLR6 ▸ RRAS ▸ SMARCB1 ▸ IL7 ▸ CARD9 ▸
IL25 ▸ IL32 ▸ IL9 ▸ MDM2 ▸ SMPD1 ▸ MUC12 ▸ MUC2 ▸
IL26 ▸ CD79B ▸ KDR ▸ MUC8 ▸ MUC22 ▸ CARD11 ▸ MUC13 ▸
SMARCC1 ▸ MUC20 ▸ SMARCA4 ▸ GATA1 ▸ TLR9 ▸ SMARCD1 ▸ BECN1 ▸
HMOX1 ▸ TOP1 ▸ ACTL6A ▸ STX1A ▸ IL22 ▸ MUC1 ▸ MUC7 ▸
IL13 ▸ ANGPT2 ▸ MUC15 ▸ CDK8 ▸ MUC4 ▸ ACHE ▸ UCN ▸
FOXO3 ▸ MUC17 ▸ CARD6 ▸ ARID1A ▸ IKBKB ▸ IL19 ▸ PAK1 ▸
SMARCC2 ▸ ABCC6 ▸ HSPD1 ▸ CCND1 ▸ IRF3 ▸ ROCK2 ▸ MUC21 ▸
IL31 ▸ IL34 ▸ MUC6 ▸ SYT1 ▸ MUC16 ▸ MSC ▸ IL37 ▸
SMARCD2 ▸ IL27 ▸ SMARCA2 ▸ SMARCE1 ▸ CCL2 ▸ CDA ▸ LYN ▸
PLD1 ▸ MAP2K4 ▸ VCP ▸ GDNF ▸ RASA1 ▸ FOXO1 ▸ VIM ▸
IRF4 ▸ CARD17 ▸ CEP44 ▸ CEP95 ▸ VDAC1 ▸ ARSA ▸ CEP250 ▸
ME2 ▸ CARD18 ▸ H2AFX ▸ CEP164 ▸ PLD2 ▸ CEP112 ▸ GRB7 ▸
CEP76 ▸ GRK1 ▸ BIRC8 ▸ HIP1 ▸ NUP214 ▸ TARDBP ▸ PRKCG ▸
CEP85 ▸ PRKAR2B ▸ HIST2H2BE ▸ HSP90AA1 ▸ ADIPOQ ▸ MAP2K3 ▸ CCR7 ▸
SLC17A5 ▸ SOAT1 ▸ PRKACG ▸ GRB14 ▸ PLOD2 ▸ NUP210 ▸ EPX ▸
CEP135 ▸ CEP72 ▸ PTK2 ▸ BCL2L12 ▸ CEP55 ▸ PANX1 ▸ NPY6R ▸
PXN ▸ IRF2 ▸ CEP192 ▸ WNT1 ▸ CALM3 ▸ IKBKG ▸ CEP104 ▸
CEP89 ▸ SETBP1 ▸ SKP1 ▸ PRKAR1A ▸ MAP2K5 ▸ PSMD10 ▸ ELAVL1 ▸
CARD16 ▸ GRB2 ▸ SETD2 ▸ ALK ▸ NUP153 ▸ PRKAR2A ▸ CEP19 ▸
GRK5 ▸ LYPLA1 ▸ CEP97 ▸ CEP70 ▸ PEA15 ▸ EHMT1 ▸ LAT ▸
SLC9A1 ▸ PSEN1 ▸ PRKCA ▸ TCHP ▸ TRAF2 ▸ CUL1 ▸ SP1 ▸
CDK4 ▸ ANGPT1 ▸ MAP2K7 ▸ DST ▸ CEP78 ▸ E2F1 ▸ PRKAR1B ▸
IRF5 ▸ CD40 ▸ DERL1 ▸ CARD14 ▸ CEP152 ▸ VIMP ▸ HUNK ▸
CARD10 ▸ SLCO6A1 ▸ CEP63 ▸ ATG5 ▸ GUCY2D ▸ PTEN ▸ BACE1 ▸
SEC14L2 ▸ PTBP1 ▸ GRK4 ▸ HSF1 ▸ GRK6 ▸ MIF ▸ CEP41 ▸
TNFRSF10A ▸ PIDD ▸ CEP170 ▸ CD47 ▸ ARC ▸ BIRC5 ▸ PRKACB ▸
DES ▸ IGF1R ▸ CEP290 ▸ MAP2K6 ▸ ALB ▸ CEP350 ▸ IL1RN ▸
CEP68 ▸ GRB10 ▸ NUP62 ▸ MEPE ▸ GRK7 ▸ MPST ▸ NPM1 ▸
CEP128 ▸ TRAF3 ▸ CEP120 ▸ PTHLH ▸ CEP57 ▸ TNFRSF8 ▸ PPT1 ▸
ACSM3 ▸ APOBEC3D ▸ MTA3 ▸ TRA ▸ CDK19 ▸ CDK1 ▸ SUB1 ▸
MT4 ▸ MAP2 ▸ ANG ▸ SMAD7 ▸ CDK16 ▸ CCR5 ▸ CALB1 ▸
ACAD8 ▸ WNT3A ▸ PRKAG2 ▸ SREBF1 ▸ EML2 ▸ CCR3 ▸ EIF4G2 ▸
VDAC2 ▸ TIMP3 ▸ PLD5 ▸ SAA1 ▸ NTF3 ▸ PRKAB2 ▸ SERPINB9 ▸
ATF5 ▸ PRG4 ▸ QRICH1 ▸ PPP1R3A ▸ DYRK1A ▸ HTRA3 ▸ IRF7 ▸
HRD ▸ PRG2 ▸ ATM ▸ DAPK2 ▸ IAPP ▸ MICE ▸ CTSL ▸
FHIT ▸ MAP3K7 ▸ RIPK4 ▸ COP ▸ IRF8 ▸ KLK3 ▸ DLG1 ▸
ANXA6 ▸ ZGLP1 ▸ MED24 ▸ CCR9 ▸ FOXP3 ▸ CDCA5 ▸ HRK ▸
MTOR ▸ GNRH1 ▸ SATB1 ▸ CDK15 ▸ TAC3 ▸ CCR4 ▸ LRRC59 ▸
CYR61 ▸ MED1 ▸ RAD1 ▸ CALML3 ▸ ETS2 ▸ KLKB1 ▸ E2F3 ▸
CALR ▸ RAB5A ▸ STX2 ▸ TRAF5 ▸ PAN2 ▸ CDK14 ▸ RAD18 ▸
GYS2 ▸ CFL1 ▸ TAC4 ▸ AFP ▸ KLF4 ▸ NR0B1 ▸ CDK20 ▸
CD2 ▸ STSP1 ▸ MST1R ▸ ADH5 ▸ IGFBP3 ▸ IRS1 ▸ LRP1 ▸
MED21 ▸ GHSR ▸ NUAK1 ▸ APEX1 ▸ CCR6 ▸ TMED7 ▸ DNAJC5 ▸
PLD4 ▸ NACA ▸ TGFB3 ▸ BLM ▸ MED15 ▸ NTN1 ▸ JAK3 ▸
DIDO1 ▸ PNPLA2 ▸ QRICH2 ▸ NUP43 ▸ PSENEN ▸ RARA ▸ RAC3 ▸
TRAF7 ▸ GJA1 ▸ FAF1 ▸ PC ▸ SREBF2 ▸ SDS ▸ EDNRA ▸
ATG3 ▸ IDO1 ▸ CDC42 ▸ THBS1 ▸ GRP ▸ CCNC ▸ GPI ▸
NANOG ▸ SMAD3 ▸ RANBP2 ▸ ABCD1 ▸ SHC1 ▸ NLRP7 ▸ RAD50 ▸
PRG3 ▸ FAM168B ▸ STC1 ▸ CD8B ▸ GYS1 ▸ RUNX3 ▸ HMGCR ▸
TET3 ▸ HTRA1 ▸ ODC1 ▸ LGALS1 ▸ CTRL ▸ EEF1A2 ▸ PLK1 ▸
TAC1 ▸ PAN3 ▸ TNFSF12 ▸ PAEP ▸ VIP ▸ ERVK-6 ▸ PDGFB ▸
CDK13 ▸ MED12 ▸ CDK7 ▸ MED13 ▸ SRC ▸ GPX3 ▸ RHO ▸
AIP ▸ TRAF4 ▸ CENPK ▸ TYR ▸ DAP3 ▸ PSMB9 ▸ IFNA2 ▸
APIP ▸ NTF4 ▸ IRF9 ▸ SEPT4 ▸ MED25 ▸ CCL19 ▸ PMEL ▸
CTNNBL1 ▸ NPPA ▸ CAPNS1 ▸ CDK12 ▸ EIF4G1 ▸ MED8 ▸ EIF4G3 ▸
GLI1 ▸ RAD17 ▸ ITCH ▸ RAC2 ▸ CCR1 ▸ SERPINA1 ▸ CIB1 ▸
XRCC6 ▸ S100A12 ▸ PARG ▸ PRKAB1 ▸ HDAC6 ▸ NAIP ▸ IARS ▸
TGM2 ▸ KMT2A ▸ ATF2 ▸ MLYCD ▸ UCP2 ▸ MED26 ▸ PLD3 ▸
TET2 ▸ TFAP2A ▸ PRKAA2 ▸ CCR2 ▸ RAD52 ▸ SPP1 ▸ HIPK2 ▸
SERPINF1 ▸ SLPI ▸ CXCL13 ▸ CDK18 ▸ GSTT1 ▸ CDK6 ▸ CDK3 ▸
NLRC5 ▸ PIN1 ▸ CSF1 ▸ CCNH ▸ CFTR ▸ PRKAG1 ▸ ACIN1 ▸
VDAC3 ▸ TSC22D3 ▸ CDK17 ▸ JAK1 ▸ PTPN11 ▸ DAXX ▸ NAB1 ▸
SMAD4 ▸ ANP32A ▸ BNIP3 ▸ ID3 ▸ CCR8 ▸ APOE ▸ CA8 ▸
MED4 ▸ BAG3 ▸ MTA1 ▸ PGF ▸ MED17 ▸ RBL2 ▸ TNFRSF10B ▸
ADM ▸ HCLS1 ▸ MED7 ▸ NANOS2 ▸ SIVA1 ▸ RAD21 ▸ C22orf29 ▸
MT3 ▸ HDAC4 ▸ NAB2 ▸ ETS1 ▸ PLD6 ▸ GNA11 ▸ CHUK ▸
EMP3 ▸ CDK10 ▸ EMP2 ▸ HTRA4 ▸ CXCL17 ▸ CTNND1 ▸ FUT1 ▸
CISH ▸ CPOX ▸ IFIH1 ▸ BCAP31 ▸ E2F2 ▸ CRYAB ▸ GPX1 ▸
MME ▸ ING1 ▸ NLRP5 ▸ PTCH1 ▸ TET1 ▸ MED14 ▸ MTA2 ▸
CDK9 ▸ SERP2 ▸ WNK1 ▸ EMP1 ▸ PRKAA1 ▸ XAF1 ▸ CCK ▸
IFI44 ▸ CPA1 ▸ DHCR24 ▸ MED23 ▸ MED6 ▸ CCR10 ▸ PICALM ▸
TOPORS ▸ NUCB1 ▸ COL4A3 ▸ PLIN4 ▸ NCL ▸ IFT57 ▸ COL4A5 ▸
PTPN13 ▸ COL11A2 ▸ COL6A2 ▸ COL4A6 ▸ STK24 ▸ TNFAIP3 ▸ CDK11B ▸
ACTG2 ▸ TICAM2 ▸ MALT1 ▸ CHD3 ▸ COL4A4 ▸ IQGAP1 ▸ COL6A3 ▸
ITGAV ▸ ATG4D ▸ GRIA1 ▸ TNFSF14 ▸ COL1A2 ▸ COL5A1 ▸ RAB10 ▸
TUBB ▸ COL2A1 ▸ PARK7 ▸ ATN1 ▸ CD3D ▸ TRIM25 ▸ RNF135 ▸
AR ▸ TFCP2 ▸ UBC ▸ CD247 ▸ KARS ▸ CD3G ▸ CD14 ▸
SYF2 ▸ DEDD2 ▸ PIAS1 ▸ RNF34 ▸ BFAR ▸ CUL3 ▸ MAPT ▸
ATAD3A ▸ IRS4 ▸ YES1 ▸ CRADD ▸ IL1R2 ▸ USP2 ▸ RPS27L ▸
PDIA6 ▸ USP54 ▸ ARHGDIA ▸ COL4A1 ▸ LY96 ▸ TRIM28 ▸ CDK11A ▸
DNAJC7 ▸ OTUD7B ▸ CLIP3 ▸ PYCARD ▸ UBE2D1 ▸ COL11A1 ▸ BNIP3L ▸
MAP1LC3B ▸ PLA2G4B ▸ RALGDS ▸ TUBA1C ▸ HNRNPH2 ▸ EIF4A1 ▸ COL3A1 ▸
CD3E ▸ SQSTM1 ▸ ITGB3 ▸ MAP3K14 ▸ COL7A1 ▸ PIDD1 ▸ EZR ▸
CLTC ▸ MYO9A ▸ DDX28 ▸ TUBA1A ▸ RPS27 ▸ UBB ▸ TNFRSF25 ▸
PCYT1A ▸ PLEC ▸ IL1R1 ▸ SPARC ▸ UBE2L3 ▸ COL6A1 ▸ COL5A2 ▸
ITGA2 ▸ CASP8AP2 ▸ FIS1 ▸ MAP1LC3A ▸ UBR5 ▸ KRR1 ▸ EIF3S10 ▸
RALBP1 ▸ MSN ▸ SORBS1 ▸ NR1H4 ▸ NUCB2 ▸ PRKCI ▸ COPS6 ▸
ITGB1 ▸ HIST1H4A ▸ PTPN6 ▸ KHDRBS1 ▸ ACTA2 ▸ NEFH ▸ NOL3 ▸
EP300 ▸ MAP4K4 ▸ EDA2R ▸ PARK2 ▸ COL1A1 ▸
Data information
Please see the Gene Interactions Track Manual.