Gene interactions and pathways from curated databases and text-mining
CASP8: top 25 interacting genes (chr2:202125258-202152432)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only CASP8-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with CASP8, not among the Top 25
Other genes interacting with CASP8. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

AKT3 ▸ XIAP ▸ IL1B ▸ FASLG ▸ MAPK3 ▸ DIABLO ▸ IL1A ▸
BCL9 ▸ BCL5 ▸ BCL6 ▸ BCL3 ▸ EPHB2 ▸ MAPK1 ▸ IRF6 ▸
MAPK6 ▸ MAPK12 ▸ MAPK14 ▸ MAPK9 ▸ MAPK8 ▸ MAPK13 ▸ MAPK7 ▸
MAPK10 ▸ MAPK15 ▸ MAPK4 ▸ MAPK11 ▸ IFNG ▸ CASP3 ▸ APAF1 ▸
CAPN1 ▸ CAPN10 ▸ CAPN3 ▸ CAPN13 ▸ CAPN11 ▸ CAPN8 ▸ CAPN6 ▸
CAPN15 ▸ CAPN12 ▸ CAPN7 ▸ CAPN5 ▸ CAPN14 ▸ CAPN9 ▸ CAPN2 ▸
FADD ▸ IL18 ▸ STS ▸ ASIP ▸ DNTT ▸ MCL1 ▸ MMP2 ▸
MMP9 ▸ MMP12 ▸ MMP11 ▸ MMP14 ▸ MMP3 ▸ MMP1 ▸ MMP27 ▸
MMP28 ▸ MMP16 ▸ MMP25 ▸ NLRP3 ▸ CDKN1A ▸ MMP26 ▸ MMP7 ▸
MMP10 ▸ MMP17 ▸ MMP21 ▸ MMP8 ▸ MMP24 ▸ MMP15 ▸ MMP19 ▸
MMP20 ▸ MMP13 ▸ CASP9 ▸ JUN ▸ PDCD5 ▸ PDCD11 ▸ CASP12 ▸
CFLAR ▸ RNF19A ▸ PDCD1 ▸ PDCD10 ▸ PDCD6 ▸ PDCD4 ▸ PDCD7 ▸
PDCD2 ▸ CYCS ▸ NA ▸ CASP1 ▸ IGF1 ▸ ANXA5 ▸ CASP2 ▸
PCBD1 ▸ INS ▸ AHSA1 ▸ TGFB1 ▸ MPZ ▸ CASP6 ▸ HLA-DRB1 ▸
PI3 ▸ CASP7 ▸ NLRC4 ▸ CASP14 ▸ EPO ▸ CASP4 ▸ CASP10 ▸
CASP16 ▸ PIK3CA ▸ PIK3R1 ▸ CASP5 ▸ TNFRSF1A ▸ PRKCD ▸ DDIT3 ▸
NOS2 ▸ DISC1 ▸ DISC2 ▸ DFFA ▸ TAT ▸ PRDX2 ▸ IL6 ▸
PCNA ▸ GRAP2 ▸ CRK ▸ MYLIP ▸ GSK3B ▸ EGF ▸ BIRC2 ▸
IL4 ▸ CTSB ▸ SOD1 ▸ CAST ▸ EIF2AK2 ▸ VEGFA ▸ IL8 ▸
CTNNB1 ▸ IRF1 ▸ NOS1 ▸ PTGS2 ▸ BID ▸ PAK2 ▸ DFFB ▸
NGF ▸ LEP ▸ DNASE1 ▸ P2RX7 ▸ APP ▸ ALPI ▸ HGF ▸
ROCK1 ▸ DNASE2 ▸ ABL1 ▸ SOD2 ▸ TCF4 ▸ IFI27 ▸ APEH ▸
FOS ▸ BDNF ▸ MYC ▸ RIPK1 ▸ CDK2 ▸ MAP3K1 ▸ IL16 ▸
BCR ▸ IFNB1 ▸ CAT ▸ TCF7 ▸ TCF19 ▸ NOS3 ▸ TCF21 ▸
TCF12 ▸ IL2 ▸ NOD2 ▸ UPK3B ▸ NFKBIA ▸ TCF24 ▸ TCF23 ▸
BMP1 ▸ NOX1 ▸ TCF25 ▸ TCF20 ▸ CA2 ▸ CSF2 ▸ MAP2K1 ▸
HDAC2 ▸ RAC1 ▸ IL10 ▸ TLR2 ▸ CTSD ▸ HTRA2 ▸ TCF15 ▸
TCF3 ▸ AIM2 ▸ TLR3 ▸ ARSK ▸ POLDIP2 ▸ PRKDC ▸ BAD ▸
CSF3 ▸ NLRP1 ▸ TLR4 ▸ ADCYAP1 ▸ BMP4 ▸ GAL ▸ LMNB1 ▸
CDC73 ▸ HSPA5 ▸ BIRC7 ▸ NOX4 ▸ FGF2 ▸ ITIH4 ▸ BIRC3 ▸
CD8A ▸ SOD3 ▸ STAT1 ▸ MAGT1 ▸ HDAC1 ▸ ATP5O ▸ APOB ▸
HPR ▸ STAT3 ▸ PAF1 ▸ IL15 ▸ WDR61 ▸ TRAF6 ▸ IL33 ▸
BMP6 ▸ AGTR1 ▸ CD79A ▸ BMP15 ▸ KRT18 ▸ IL5 ▸ PDLIM7 ▸
CARD8 ▸ CDK5 ▸ HSPB1 ▸ NOX3 ▸ BMP10 ▸ PPP2R2B ▸ ENDOG ▸
GZMB ▸ HMGB1 ▸ IL3 ▸ TLR5 ▸ BMP7 ▸ SNAP25 ▸ BMP3 ▸
IL11 ▸ LEO1 ▸ NOD1 ▸ CTR9 ▸ RB1 ▸ TLR7 ▸ PPP2CA ▸
NOX5 ▸ PML ▸ MST1 ▸ RIPK2 ▸ SMPD2 ▸ BMP5 ▸ PPP2R1A ▸
BMP2 ▸ PRNP ▸ CCDC88A ▸ RBBP4 ▸ HTT ▸ IGF2 ▸ EGFR ▸
TXN ▸ GP2 ▸ LPA ▸ CD4 ▸ GP5 ▸ IL21 ▸ MAP2K2 ▸
PLCG1 ▸ BIRC6 ▸ SYK ▸ IL24 ▸ CDC6 ▸ PTX3 ▸ RAD51 ▸
CREB5 ▸ EIF2S1 ▸ RIPK3 ▸ ANXA1 ▸ MET ▸ PGP ▸ TLR8 ▸
NPS ▸ CSE ▸ TLR1 ▸ WAS ▸ PPARA ▸ GSN ▸ CXCL9 ▸
RBBP7 ▸ ICAM1 ▸ APC ▸ CREB3 ▸ CREB1 ▸ JAK2 ▸ BOC ▸
LMNB2 ▸ TLR10 ▸ CDH1 ▸ HIF1A ▸ PTX4 ▸ TNFRSF1B ▸ IL20 ▸
GP6 ▸ GP9 ▸ SMARCD2 ▸ SMARCC1 ▸ MUC12 ▸ IL7 ▸ MUC17 ▸
KDR ▸ PPARG ▸ IL13 ▸ RAF1 ▸ MUC8 ▸ ABCC6 ▸ MEFV ▸
MUC7 ▸ TLR9 ▸ SMARCC2 ▸ MUC22 ▸ SMARCD1 ▸ FOXO3 ▸ PLD1 ▸
MUC16 ▸ IL9 ▸ SMARCE1 ▸ MUC20 ▸ CD79B ▸ IL27 ▸ IKBKB ▸
CDK8 ▸ IL19 ▸ RRAS ▸ TLR6 ▸ ARID1A ▸ TOP1 ▸ MUC15 ▸
HMOX1 ▸ STX1A ▸ CARD6 ▸ GATA1 ▸ CCND1 ▸ BECN1 ▸ IL25 ▸
SMARCA4 ▸ IL31 ▸ ACTL6A ▸ MUC2 ▸ CARD9 ▸ SMARCB1 ▸ CARD11 ▸
RENBP ▸ UCN ▸ IL26 ▸ ROCK2 ▸ CCL2 ▸ SMARCA2 ▸ ACHE ▸
IL22 ▸ MUC13 ▸ MUC21 ▸ IL37 ▸ MDM2 ▸ IL32 ▸ IL34 ▸
SMPD1 ▸ MUC1 ▸ MUC4 ▸ HSPD1 ▸ ANGPT2 ▸ IRF3 ▸ TRAF1 ▸
MUC19 ▸ MSC ▸ MUC6 ▸ CDA ▸ BRCA1 ▸ PAK1 ▸ SYT1 ▸
LYN ▸ MIF ▸ TRAF3 ▸ CARD14 ▸ ARSA ▸ CEP290 ▸ GRB2 ▸
CEP44 ▸ PLOD2 ▸ CEP55 ▸ CEP63 ▸ CEP250 ▸ VDAC1 ▸ ADIPOQ ▸
MEPE ▸ PTEN ▸ HIST2H2BE ▸ SLCO6A1 ▸ ME2 ▸ NUP210 ▸ EHMT1 ▸
GDNF ▸ DES ▸ PTHLH ▸ SP1 ▸ VIM ▸ CDK4 ▸ ATG5 ▸
SLC17A5 ▸ ARC ▸ SETD2 ▸ NPY6R ▸ SOAT1 ▸ PRKAR1B ▸ IKBKG ▸
HSP90AA1 ▸ PIDD ▸ CEP350 ▸ CEP164 ▸ DERL1 ▸ PSMD10 ▸ PXN ▸
LYPLA1 ▸ PLD2 ▸ PTK2 ▸ HUNK ▸ IRF5 ▸ TARDBP ▸ CD47 ▸
TNFRSF10A ▸ HSF1 ▸ MPST ▸ PRKACB ▸ CEP128 ▸ GRB7 ▸ CEP76 ▸
IGF1R ▸ CCR7 ▸ CEP68 ▸ NUP214 ▸ PRKAR1A ▸ NPM1 ▸ GRK6 ▸
CARD16 ▸ PRKAR2B ▸ PSEN1 ▸ ALB ▸ BIRC5 ▸ CEP135 ▸ HIP1 ▸
CARD10 ▸ CUL1 ▸ CEP78 ▸ IL1RN ▸ CEP152 ▸ SLC9A1 ▸ ANGPT1 ▸
CD40 ▸ CEP120 ▸ SEC14L2 ▸ PRKACG ▸ CEP85 ▸ GUCY2D ▸ GRK7 ▸
GRB14 ▸ DST ▸ PRKAR2A ▸ CEP112 ▸ WNT1 ▸ TCHP ▸ CEP70 ▸
MAP2K4 ▸ LAT ▸ GRK4 ▸ SETBP1 ▸ PANX1 ▸ GRK5 ▸ BACE1 ▸
GRB10 ▸ PEA15 ▸ ELAVL1 ▸ PTBP1 ▸ MAP2K3 ▸ CEP104 ▸ BIRC8 ▸
BCL2L12 ▸ CEP170 ▸ EPX ▸ MAP2K7 ▸ CEP89 ▸ E2F1 ▸ CEP57 ▸
IRF4 ▸ CEP19 ▸ IRF2 ▸ CEP72 ▸ CALM3 ▸ CEP192 ▸ H2AFX ▸
VCP ▸ RASA1 ▸ CARD18 ▸ NUP62 ▸ PRKCG ▸ FOXO1 ▸ CEP95 ▸
MAP2K5 ▸ SKP1 ▸ PRKCA ▸ CEP41 ▸ MAP2K6 ▸ GRK1 ▸ ALK ▸
CEP97 ▸ CARD17 ▸ TRAF2 ▸ VIMP ▸ NUP153 ▸ GNRH1 ▸ IFI44 ▸
EIF4G3 ▸ CCL19 ▸ MED15 ▸ CTNNBL1 ▸ LGALS1 ▸ AIP ▸ DAPK2 ▸
DIDO1 ▸ APIP ▸ CPOX ▸ CCR6 ▸ BNIP3 ▸ GLI1 ▸ STX2 ▸
EIF4G1 ▸ ZGLP1 ▸ CTSL ▸ CCR1 ▸ PTCH1 ▸ NTN1 ▸ HRK ▸
CTNND1 ▸ CDK12 ▸ ADM ▸ MTA2 ▸ TNFRSF8 ▸ ODC1 ▸ CRYAB ▸
MTOR ▸ GNA11 ▸ CDK6 ▸ IARS ▸ CCNH ▸ TAC1 ▸ TIMP3 ▸
CCR8 ▸ TSC22D3 ▸ NUP43 ▸ TGFB3 ▸ MME ▸ SRC ▸ RBL2 ▸
APOBEC3D ▸ SERP2 ▸ GHSR ▸ ATF5 ▸ KMT2A ▸ TAC3 ▸ HTRA3 ▸
CALB1 ▸ CFL1 ▸ CDK20 ▸ EMP1 ▸ AFP ▸ ABCD1 ▸ EIF4G2 ▸
FAM168B ▸ SLPI ▸ KLF4 ▸ CCR5 ▸ MED24 ▸ CDK1 ▸ NACA ▸
TMED7 ▸ GSTT1 ▸ TNFRSF10B ▸ LRP1 ▸ MED8 ▸ CDK10 ▸ MED17 ▸
CDK14 ▸ NPPA ▸ TAC4 ▸ FHIT ▸ PTPN11 ▸ DAP3 ▸ SAA1 ▸
CDK3 ▸ RAD50 ▸ NANOS2 ▸ SERPINF1 ▸ ANP32A ▸ BAG3 ▸ FUT1 ▸
XRCC6 ▸ MT3 ▸ ACIN1 ▸ ING1 ▸ PLD3 ▸ CD2 ▸ GYS2 ▸
CCK ▸ PAN2 ▸ ITCH ▸ CENPK ▸ PRKAG1 ▸ HTRA1 ▸ ANXA6 ▸
CCR2 ▸ ETS1 ▸ E2F2 ▸ THBS1 ▸ SMAD4 ▸ MED13 ▸ GJA1 ▸
MICE ▸ C22orf29 ▸ DLG1 ▸ CCR9 ▸ SATB1 ▸ EMP2 ▸ IRF8 ▸
MTA3 ▸ HDAC6 ▸ DHCR24 ▸ IFIH1 ▸ SDS ▸ DAXX ▸ CD8B ▸
DNAJC5 ▸ SPP1 ▸ NAIP ▸ CCR3 ▸ CA8 ▸ EEF1A2 ▸ WNK1 ▸
MED14 ▸ CXCL13 ▸ PRKAB2 ▸ PGF ▸ FOXP3 ▸ RAD1 ▸ MED1 ▸
PDGFB ▸ PIN1 ▸ PPT1 ▸ TRAF4 ▸ RAD21 ▸ SMAD7 ▸ CDK18 ▸
SERPINA1 ▸ MED25 ▸ GPX3 ▸ CDK16 ▸ RANBP2 ▸ ATG3 ▸ LRRC59 ▸
HRD ▸ RUNX3 ▸ TRAF5 ▸ ADH5 ▸ STC1 ▸ VIP ▸ CDK9 ▸
ERVK-6 ▸ KLKB1 ▸ SREBF1 ▸ CTRL ▸ CCR4 ▸ IRF9 ▸ TGM2 ▸
HTRA4 ▸ CAPNS1 ▸ PNPLA2 ▸ PRG3 ▸ SUB1 ▸ CISH ▸ SMAD3 ▸
PLD4 ▸ CIB1 ▸ PRG4 ▸ BCAP31 ▸ IRS1 ▸ PLD5 ▸ HDAC4 ▸
CDCA5 ▸ DYRK1A ▸ QRICH2 ▸ MTA1 ▸ CPA1 ▸ NLRP5 ▸ RAD18 ▸
PPP1R3A ▸ TYR ▸ MED6 ▸ GPI ▸ CDK19 ▸ MED7 ▸ PC ▸
MED12 ▸ GPX1 ▸ PSENEN ▸ MED23 ▸ PLD6 ▸ TET2 ▸ ATM ▸
RAB5A ▸ PLK1 ▸ MT4 ▸ RHO ▸ MAP2 ▸ PRKAG2 ▸ COP ▸
ATF2 ▸ CYR61 ▸ RAC2 ▸ PMEL ▸ CDK15 ▸ RAD17 ▸ MST1R ▸
PAN3 ▸ ID3 ▸ RIPK4 ▸ EML2 ▸ ETS2 ▸ PARG ▸ BLM ▸
SEPT4 ▸ SERPINB9 ▸ XAF1 ▸ SHC1 ▸ RAD52 ▸ SIVA1 ▸ MED26 ▸
NUAK1 ▸ MLYCD ▸ NAB2 ▸ NTF4 ▸ CSF1 ▸ PAEP ▸ HMGCR ▸
HCLS1 ▸ FAF1 ▸ UCP2 ▸ CXCL17 ▸ VDAC3 ▸ CDK13 ▸ MED21 ▸
VDAC2 ▸ TET3 ▸ CFTR ▸ IDO1 ▸ TFAP2A ▸ CALR ▸ IRF7 ▸
IGFBP3 ▸ STSP1 ▸ NLRP7 ▸ PSMB9 ▸ E2F3 ▸ APEX1 ▸ NTF3 ▸
EMP3 ▸ NAB1 ▸ NANOG ▸ CDK17 ▸ ACSM3 ▸ KLK3 ▸ PRG2 ▸
IAPP ▸ NLRC5 ▸ WNT3A ▸ HIPK2 ▸ PRKAA1 ▸ CDK7 ▸ MAP3K7 ▸
S100A12 ▸ EDNRA ▸ CALML3 ▸ TET1 ▸ CDC42 ▸ TRA ▸ NR0B1 ▸
ANG ▸ SREBF2 ▸ GYS1 ▸ RAC3 ▸ APOE ▸ CCR10 ▸ PRKAB1 ▸
GRP ▸ QRICH1 ▸ JAK1 ▸ MED4 ▸ JAK3 ▸ RARA ▸ IFNA2 ▸
TNFSF12 ▸ CCNC ▸ ACAD8 ▸ CHUK ▸ PRKAA2 ▸ TRAF7 ▸ PLEC ▸
CASP8AP2 ▸ KARS ▸ CDK11A ▸ ACTG2 ▸ ARHGDIA ▸ OTUD7B ▸ COL11A2 ▸
STK24 ▸ RALGDS ▸ ITGA2 ▸ CLIP3 ▸ SQSTM1 ▸ EIF3S10 ▸ ATN1 ▸
COL1A2 ▸ RPS27 ▸ NEFH ▸ UBE2D1 ▸ MAP3K14 ▸ COL4A4 ▸ BNIP3L ▸
MAP1LC3B ▸ CD3D ▸ TNFSF14 ▸ COL7A1 ▸ PIDD1 ▸ RALBP1 ▸ TNFAIP3 ▸
PYCARD ▸ ITGB3 ▸ PLIN4 ▸ SYF2 ▸ LY96 ▸ CDK11B ▸ PLA2G4B ▸
CLTC ▸ IFT57 ▸ COL6A2 ▸ PARK7 ▸ EDA2R ▸ IL1R1 ▸ ACTA2 ▸
DDX28 ▸ COL4A3 ▸ MYO9A ▸ NOL3 ▸ EP300 ▸ CHD3 ▸ HNRNPH2 ▸
ATG4D ▸ COL6A3 ▸ BFAR ▸ PCYT1A ▸ CD3E ▸ UBC ▸ TICAM2 ▸
UBR5 ▸ PICALM ▸ USP2 ▸ DEDD2 ▸ TNFRSF25 ▸ COL4A6 ▸ AR ▸
CD14 ▸ TUBA1A ▸ TRIM28 ▸ CD247 ▸ TUBA1C ▸ RNF135 ▸ RPS27L ▸
EZR ▸ TOPORS ▸ TFCP2 ▸ SPARC ▸ PRKCI ▸ COPS6 ▸ YES1 ▸
UBB ▸ ATAD3A ▸ CRADD ▸ MAP1LC3A ▸ GRIA1 ▸ COL11A1 ▸ PDIA6 ▸
COL5A2 ▸ RNF34 ▸ NCL ▸ ITGB1 ▸ COL1A1 ▸ COL2A1 ▸ TUBB ▸
USP54 ▸ MAP4K4 ▸ PTPN6 ▸ COL5A1 ▸ KRR1 ▸ COL4A5 ▸ DNAJC7 ▸
NUCB2 ▸ COL4A1 ▸ COL3A1 ▸ MALT1 ▸ IL1R2 ▸ IRS4 ▸ ITGAV ▸
MAPT ▸ FIS1 ▸ MSN ▸ RAB10 ▸ COL6A1 ▸ EIF4A1 ▸ PARK2 ▸
PIAS1 ▸ HIST1H4A ▸ CD3G ▸ KHDRBS1 ▸ PTPN13 ▸ NR1H4 ▸ NUCB1 ▸
IQGAP1 ▸ CUL3 ▸ SORBS1 ▸ UBE2L3 ▸ TRIM25 ▸
Data information
Please see the Gene Interactions Track Manual.