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Strieder et al., J Biol Chem 2003
(Neuroblastoma) :
Inhibition of E2F activity in MYCN amplified cells by the overexpression of p16(INK4A) reduced MYCN expression
Kramps et al., J Biol Chem 2004
(Neuroblastoma) :
However, in a neuroblastoma cell line that does not express MYCN, overexpression of E2F-1 was not sufficient to activate the MYCN promoter even in the presence of trichostatin A and 5-aza-cytidine
Nowak et al., Nucleic Acids Res 2006
(Nervous System Neoplasms...) :
We have previously shown activation of the oncogene MYCN by E2F Ciechanover et al., J Biol Chem 1994
:
The process of recognition appears to be selective ; E2-F1 is not required for the conjugation and degradation of human N-myc ... The process of recognition appears to be selective ; E2-F1 is not required for the conjugation and degradation of human N-myc