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EPHB2 — NOS2

Text-mined interactions from Literome

Chan et al., Infect Immun 2001 : Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK , MKK7-JNK, and NF-kappaB signaling pathways
Chang et al., Arch Toxicol 2001 : These results provide evidence to suggest that exposure to cigarette smoke results in oxidant stress which leads to the stimulation of iNOS and c-fos together with the induction of protein tyrosine phosphorylation and MEK1/ERK2 which in turn may promote lung pathogenesis
Cho et al., Nitric Oxide 2002 (MAP Kinase Signaling System) : These results demonstrated that bovine type I collagen induces iNOS in serum stimulated murine macrophages through JunB/AP-1 and NF-kappa B activation and that activation of ERK1/2 plays an essential role in JunB/AP-1 activation
Adams et al., Cardiovasc Res 2002 (Heart Failure) : The cytokine mediated iNOS induction was significantly reduced by blocking ERK1/ERK2 activation and completely abolished by the inhibition of NFkappaB
Slomiany et al., Biochem Biophys Res Commun 2002 (MAP Kinase Signaling System) : Porphyromonas gingivalis lipopolysaccharide interferes with salivary mucin synthesis through inducible nitric oxide synthase activation by ERK and p38 kinase
Jiang et al., Arterioscler Thromb Vasc Biol 2002 (MAP Kinase Signaling System) : Treatment of VSMCs with PDGF or EGF alone potently induced ERK phosphorylation and DNA synthesis but did not induce NF-kappaB activation or iNOS expression ... Inhibition of ERK phosphorylation with selective inhibitors ( PD98059 or U0126 ) attenuated interleukin-1beta induced persistent NF-kappaB activation and iNOS expression in either the absence or presence of the growth factors
Maggi et al., J Biol Chem 2003 (Cardiovirus Infections...) : The regulation of macrophage activation by ERK appears to be selective for IL-1, as ERK inhibition does not attenuate dsRNA induced iNOS expression by macrophages
Lee et al., Life Sci 2003 : In addition, phosphorylations of MAPKs ( ERK 1/2, p38, JNK 1/2 ) were increased by LT. LT-induced iNOS mRNA level was inhibited by PD98059 ( MEK 1/2 inhibitor ), SB203580 ( p38 inhibitor ), and cycloheximide ( a protein synthesis blocker ), indicating that the phosphorylation of ERK 1/2 and p38, and on-going protein synthesis are necessary for LT-induced iNOS expression
Choi et al., J Neurosci 2003 (Disease Progression...) : Inhibition of ERK1/2 and p38 MAPK reduced iNOS and COX-2 mRNA expression and rescued dopaminergic neurons in the SN
Sung et al., J Neurochem 2005 (Hyperalgesia) : In contrast, both ERK and JNK inhibitor pretreatments only partially ( approximately 50 % ) inhibited the IL-1beta induced iNOS expression in the spinal cord
Lee et al., Infect Immun 2005 : This correlated with the requirement for ERK1/2 in TNF-alpha but not NOS2 promoter activity ... Our data indicate that the increased Ets/Elk and NF-kappaB promoter activities associated with M. smegmatis infected macrophages are responsible, at least in part, for the increased TNF-alpha and NOS2 production observed in these infected cells and that ERK1/2 is required for Ets/Elk activity and full TNF-alpha production
Larsen et al., Diabetologia 2005 : However, inhibition of ERK reduced NFkappaB mediated Nos2 expression ; serine 276 phosphorylation of the p65 unit of the NFkappaB complex seemed critical, as evaluated by amino acid mutation analysis ... ERK activity is required for NFkappaB mediated transcription of Nos2 in insulin producing INS-1E cells, indicating that ERK regulates Nos2 expression by increasing the transactivating capacity of NFkappaB
Saito et al., J Pharmacol Sci 2005 : ERK activation, iNOS induction , and NO production following LPS stimulation were all markedly inhibited in the presence of U0126, an ERK inhibitor
Smyth et al., Immunology 2006 : Inhibition of ERK activity, by the inhibitor U0126, reduced LPS induced iNOS expression in our cell lines
Suh et al., Arch Biochem Biophys 2006 : These results suggest that the transcription factor NF-kappaB is involved in ERK mediated iNOS regulation and that activation of the Ras/ERK pathway contributes to the induction of iNOS expression in RAW264.7 cells in response to LPS
Korkmaz et al., Pharmacology 2006 : The endotoxin induced increase in the EC ( 50 ) value of norepinephrine was decreased by phenylene-1,3-bis [ ethane-2-isothiourea ] dihydrobromide ( 1,3-PBIT ), a selective inducible NO synthase inhibitor, and U0126, a selective inhibitor of ERK1/2 phosphorylation by MAPK kinase
Weng et al., J Infect Dis 2006 (Disease Models, Animal...) : Short-term intravesical instillation of UPEC enhances detrusor contractions through an eNOS related pathway, but iNOS regulated ERK1/2 signaling may be involved in long-term UPEC treatment induced responses
Donnini et al., FASEB J 2007 (Carcinoma, Squamous Cell...) : Consistently, iNOS-GC pathway inhibitors blocked mitogen activated protein kinase-ERK1/2 phosphorylation, which was required to mediate PGE2 functions ... Silencing of iNOS also impaired EGFR induced ERK1/2 phosphorylation
Choi et al., Eur J Pharmacol 2007 : Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-kappaB, ERK1/2 , and p38 kinase ... These results suggest that isoeugenol and its analogues inhibit NO production and iNOS expression in LPS stimulated RAW 264.7 cells, and that these effects are mediated , at least in part, by blocking the phosphorylation of ERK1/2 and p38 kinase, degradation of I-kappaBalpha, and activation of NF-kappaB
Thellung et al., Glia 2007 (Gliosis...) : In microglial cells, NO release, dependent on the expression of the inducible NO synthase (iNOS), and the secretion of the chemokine CCL5 were Ca ( 2+ ) dependent and under the control of the MAP kinases ERK1/2 and p38 : ERK1/2 inhibition, using PD98059, reduced iNOS expression, while p38 blockade by PD169316 inhibited CCL5 release
Zhang et al., J Biol Chem 2007 : Increased iNOS activity was dependent on B1R activation of the MAPK ERK
Woo et al., Circ Res 2008 (Diabetes Mellitus...) : Shear stress induced extracellular signal regulated kinase ( ERK ) 5 activation and the consequent regulation of Kruppel-like factor 2 and endothelial nitric oxide synthase expression represents one of the antiinflammatory and vascular tone regulatory mechanisms maintaining normal endothelial function
Calvisi et al., Carcinogenesis 2008 (Carcinoma, Hepatocellular...) : Suppression of iNOS signaling by aminoguanidine led to decreased HCC growth and NF-kB and RAS/ERK expression and increased apoptosis both in vivo and in vitro
Shi et al., Nan Fang Yi Ke Da Xue Xue Bao 2009 (Parkinson Disease, Secondary) : [ Effect of phosphorylated-ERK1/2 on inducible nitric oxide synthase expression in the substantia nigra of mice with MPTP induced Parkinson disease ] ... P-ERK1/2 may regulate the expression of iNOS to induce DA neuron loss in the SN of PD, and Rg1 may protect the DA neurons possibly by depressing nuclear translocation of P-ERK1/2
Choi et al., American journal of physiology. Renal physiology 2009 (Disease Models, Animal...) : In conclusion, this study suggests that sildenafil has antiapoptotic effects in experimental IR renal injury via ERK phosphorylation, induction of iNOS and eNOS production, and a decrease in the Bax/Bcl-2 ratio
Wu et al., Br J Pharmacol 2009 : Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity, activation of extracellular regulated kinase (ERK) , c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma
Ralay Ranaivo et al., Brain Res 2010 (MAP Kinase Signaling System) : Albumin activated ERK1/2 , p38 MAPK and JNK signaling pathways in astrocytes, and induced the production of interleukin (IL)-1beta, inducible nitric oxide (NO) synthase , the NO metabolite nitrite, and the chemokine CX3CL1 while reducing the level of S100B
Youn et al., Nutr Cancer 2009 (Colitis...) : Oral administration of resveratrol or piceatannol ( 10 mg/kg body weight each ) for 7 constitutive days attenuated the DSS induced inflammatory injury, upregulation of iNOS expression, and activation of NF-kappaB, STAT3, and ERK
Gibbs et al., J Biol Chem 2012 : Formation of ternary complex of human biliverdin reductase-protein kinase Cd-ERK2 protein is essential for ERK2 mediated activation of Elk1 protein, nuclear factor-?B, and inducible nitric-oxidase synthase (iNOS)
Lee et al., Particle and fibre toxicology 2012 (MAP Kinase Signaling System) : MWCNTs caused ERK1,2 activation and inhibition of ERK1,2 ( U0126 ) blocked MWCNT induction of COX-2 and PGE2 production, but did not reduce the induction of iNOS ... Inhibition of iNOS ( L-NAME ) did not affect ERK1,2 activation, nor did L-NAME significantly decrease COX-2 induction by MWCNT
Zhang et al., Shock 2013 : OPTmecAMP inactivated Raf1/MEK/ERK signaling, but ERK had no effect on iNOS expression
Tsai et al., J Dermatol Sci 2013 (Gram-Positive Bacterial Infections...) : ROS dependent stimulation of ERK , JNK, NF-?B, and AP-1 activation contributes to P. acnes induced iNOS/NO and COX-2/PGE ( 2 ) in macrophages, and chemicals such as hispolon possessing ability to block iNOS/NO and COX-2/PGE ( 2 ) production reserve potential to be further developed for treatment of the early phase of inflammation elicited by P. acnes
Doods et al., BioMed research international 2013 (Arrhythmias, Cardiac...) : Sabiporide reduces ischemia induced arrhythmias and myocardial infarction and attenuates ERK phosphorylation and iNOS induction in rats
Wei et al., Spine (Phila Pa 1976) 2013 : IL-1 dependent upregulation of iNOS , IL-6, Cox-2, ( MMP)-3, and MMP-13 was significantly reduced by ERK inhibition
Youn et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2013 : Collectively, this series of experiments indicates that radicicol inhibits iNOS gene expression by blocking ERK1/2 signaling