Gene interactions and pathways from curated databases and text-mining

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GRP — IL8

Text-mined interactions from Literome

Qiao et al., Neoplasia (New York, N.Y.) 2007 (Neuroblastoma) : Ets1 transcription factor mediates gastrin releasing peptide induced IL-8 regulation in neuroblastoma cells ... Our findings demonstrate that GRP upregulates proangiogenic IL-8 expression in an Ets1 dependent manner, suggesting a critical role of this process during GRP induced neuroblastoma angiogenesis and metastasis
Lee et al., Oncol Res 2013 (Adenocarcinoma...) : Hepatocyte growth factor mediated gastrin releasing peptide induces IL-8 expression through Ets-1 in gastric cancer cells ... We investigated the role of HGF induced activation of GRP and Ets-1 transcription factor in expression of the proangiogenic factor IL-8 ... In conclusion, HGF mediated the GRP induction of IL-8 expression through Ets-1, which thus might serve as a promising target for gastric cancer therapy
Hernanz et al., J Neuroimmunol 1996 : Differential effects of gastrin releasing peptide , neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects