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ANXA6 — TLR4

Text-mined interactions from Literome

Lehner et al., Immunol Lett 2005 : However, IL-12p70 production in response to Toll-like receptor ( TLR ) stimulating agents plus IFN-gamma was consistently lower in AIMV medium although also under serumfree culture conditions, nanogram quantities of IL-12 were produced
Goriely et al., Blood 2006 : Finally, experiments on DCs from IRF-3-deficient mice established that TLR4 induced IL-12p35 mRNA and IL-12p70 synthesis are impaired in absence of IRF-3
Agrawal et al., J Immunol 2006 (Encephalomyelitis, Autoimmune, Experimental...) : Consistent with this observation, dendritic cells from ERK1 ( -/- ) mice show enhanced IL-12p70 and reduced IL-10 secretion in response to TLR stimulation
Bekeredjian-Ding et al., J Immunol 2006 : T cell independent, TLR induced IL-12p70 production in primary human monocytes ... Simultaneous stimulation of TLR4 and TLR8 induced IL-12p70 in primary human monocytes
Lapteva et al., Cancer Res 2007 : Whereas neither iCD40 nor TLR-4 signaling alone led to high levels of interleukin (IL)-12p70 and IL-6, using iCD40 in combination with lipopolysaccharide (LPS) or monophosphoryl lipid A led to strongly synergistic production of both
Taneichi et al., Clin Immunol 2008 (Agammaglobulinemia...) : Stimulation with TLR2, TLR4 and TLR7/8 ligands, as well as TLR3 ligand, resulted in significantly lower production of TNF-alpha, but neither IL-6 nor IL-12p70 , by DCs from XLA patients in comparison to normal controls
Jackson et al., Int J Cancer 2008 (Melanoma...) : Melanoma-lysate markedly suppressed TLR4 dependent IL-12p40 and p70 production
Kollmann et al., J Immunol 2009 : In response to most TLR ligands, neonatal innate immune cells, including monocytes and conventional and plasmacytoid dendritic cells produced less IL-12p70 and IFN-alpha ( and consequently induced less IFN-gamma ), moderately less TNF-alpha, but as much or even more IL-1beta, IL-6, IL-23, and IL-10 than adult cells
Jung et al., Eur J Pharmacol 2010 : These results suggest that Ursolic acid modulates human dendritic cells function in a fashion that favors Th1 polarization via the activation of IL-12p70 dependent on TLR2 and/or TLR4 , and may be used on dendritic cells based vaccines for cancer immunotherapy
Song et al., Leukemia 2011 : LBH589 also significantly repressed the production of interleukin (IL)-6, IL-10, IL-12p70 , IL-23 and tumor necrosis factor-a by Toll-like receptor (TLR)3 and TLR4 induced DC activation , indicating an important role of HDAC activity in immune regulation and inflammation
Kim et al., Biomarker insights 2011 : These results suggest that URC modulates DC function in a fashion that favors Th1 polarization via the activation of IL-12p70 dependent on TLR4 signaling, and may be used on DC-based vaccine for cancer immunotherapy
Belderbos et al., Pediatr Allergy Immunol 2012 (Hypersensitivity) : Of innate immune variables, TLR3 mediated IL-12p70 production was highly associated with environmental exposures ( pets, breastfeeding and mode of delivery ), whereas TLR9 mediated cytokine responses were not associated with any environmental factor
Belderbos et al., PloS one 2012 : Suppression by neonatal plasma of TLR4 mediated IL-12p70 production, but not induction of TLR4 mediated IL-10 production, was maintained up to the age of 1 month ... The factor causing inhibition of TLR4 mediated IL-12p70 production by cord blood plasma was resistant to heat inactivation or protein depletion and was independent of IL-10, vitamin D and prostaglandin E2 ... In conclusion, human neonatal plasma contains at least two distinct factors that suppress TLR4 mediated IL-12p70 production or induce IL-10 or production
Liu et al., Eur J Immunol 2012 : This indicates that IFN-a increased the sensitivity of monocytes to IL-10, and as a result, TLR induced IL-12p70 by IFN pretreated cells was suppressed ... In summary, we demonstrate that one of the consequences of priming human APCs with IFN is to promote the cells ' sensitivity to IL-10, which leads to the inhibition of TLR induced IL-12p70 production
Compté et al., PloS one 2013 : The aim of our study was to define the relative contribution of age and clinical status on TLR induced interleukin (IL)-12p70 and IL-23 production as these cytokines play an important role in the protection against intracellular and extracellular pathogens, respectively
Fowler et al., Immunol Cell Biol 2013 : We found that Vd2 cells are indirectly activated by BCG in an interleukin (IL)-12p70 dependent manner, and that DC production of the IL-12p70 responsible for Vd2 cell activation requires Toll-like receptor 2/4 ligands from BCG and interferon ( IFN ) -? from memory CD4 T cells