UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to ERBB2

CDH1 — ERBB2

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: CDH1 → ERBB2 (decreases, CDH1 Activity) Kim et al., Cancer Lett 2009 *
Evidence: We also observed a marked reduction of an epithelial cell marker, E-cadherin, and an induction of vimentin in ErbB2-MCF10A cells, suggesting that epithelial-mesenchymal transition may play a role in the ErbB2-induced invasion and migration of MCF10A cells.
NCI Pathway Database a6b1 and a6b4 Integrin signaling: ErbB2 (ERBB2) → E-cadherin (CDH1) (cell adhesion, collaborate) Hintermann et al., J Biol Chem 2005 *, Chartier et al., J Cell Sci 2006
Evidence: expresssion pattern, mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Innatedb Interaction: ERBB2 — CDH1 (unknown, -) Ochiai et al., Biochem Biophys Res Commun 1994 *
IRef Intact Interaction: Complex of 59 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013