◀ Back to MYLIP
MYLIP — RUNX1
Text-mined interactions from Literome
Fazi et al., Cancer Cell 2007
(Leukemia) :
By recruiting chromatin remodeling enzymes at an AML1 binding site on the pre-miR-223 gene,
AML1/ETO induces heterochromatic silencing of
miR-223
Ben-Ami et al., Proc Natl Acad Sci U S A 2009
:
Induction of megakaryocytic differentiation in K562 cells by 12-o-tetradecanoylphorbol-13-acetate markedly
increased miR-27a expression, concomitantly with binding of
Runx1 to miR-27a regulatory region ... The data indicate that miR-27a plays a regulatory role in megakaryocytic differentiation by attenuating Runx1 expression, and that, during megakaryopoiesis, Runx1 and miR-27a are engaged in a feedback loop involving positive
regulation of
miR-27a expression by
Runx1
Feng et al., Br J Haematol 2009
:
We investigated the
regulation of the transcription factor
Runx1 by
microRNA (miR)-27 and the resulting effects upon the differentiation of myeloblasts into granulocytes
Zaidi et al., Cancer Res 2009
(Leukemia, Myeloid, Acute...) :
Both
Runx1 and the t ( 8 ; 21 ) -encoded AML1-ETO occupy the miR-24-23-27 locus and reciprocally
control miR-24 transcription
Li et al., Blood 2013
(Leukemia, Myeloid, Acute) :
Here, we show that
AML1/ETO triggers the heterochromatic silencing of
microRNA-193a (miR-193a) by binding at AML1 binding sites and recruiting chromatin remodeling enzymes ... Suppression of miR-193a expands the oncogenic activity of the fusion protein AML-ETO, because
miR-193a represses the expression of multiple target genes, such as
AML1/ETO , DNMT3a, HDAC3, KIT, CCND1, and MDM2 directly, and increases PTEN indirectly ... Our study identifies
miR-193a and PTEN as
targets for
AML1/ETO and provides evidence that links the epigenetic silencing of tumor suppressor genes miR-193a and PTEN to differentiation block of myeloid precursors
Sun et al., J Immunol 2013
:
Specific knockdown experiments in hematopoietic cells and rescue experiments in nonhematopoietic cells show that PU.1 is critical for
miR-142 gene expression and that it
synergizes with
Runx1 , C/EBPß, and CBFß