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Katona et al., J Biol Chem 2009
(Adenocarcinoma...) :
LCA and ent-LCA mediated apoptosis was inhibited by both pan-caspase and selective caspase-8 inhibitors, whereas a selective caspase-2 inhibitor provided no protection
Yuan et al., BioMed research international 2013
(Urinary Bladder Neoplasms) :
Moreover, LCA induced mitochondrial dysfunction, caspase-3 activation, and poly-ADP-ribose polymerase ( PARP ) cleavage, which displayed features of mitochondria dependent apoptotic signals
Goldberg et al., PeerJ 2013
:
In LNCaP and PC-3 cells, LCA triggered the extrinsic pathway of apoptosis and cell death induced by LCA was partially dependent on the activation of caspase-8 and -3