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CASP14 — PAK2

Text-mined interactions from Literome

Chan et al., J Cell Biochem 2000 (Carcinoma, Squamous Cell) : We report that genistein, an isoflavone compound with known inhibitory activities to protein tyrosine kinases ( PTKs ) and topoisomerase-II ( topo-II ), can prevent UV irradiation induced apoptotic biochemical changes ( DNA fragmentation, caspase-3 activation , and cleavage/activation of PAK2 ) in A431 cells
Chan et al., J Cell Biochem 2003 (Carcinoma, Squamous Cell) : In this study we demonstrate that curcumin ( Cur ), the yellow pigment of Curcuma longa with known anti-oxidant and anti-inflammatory properties, can prevent UV irradiation induced apoptotic changes, including c-Jun N-terminal kinase (JNK) activation, loss of mitochondrial membrane potential ( MMP ), mitochondrial release of cytochrome C, caspase-3 activation , and cleavage/activation of PAK2 in A431 cells
Jakobi et al., Drug Resist Updat 2004 (Neoplasms) : Caspase activated MEKK1 translocates from a particulate compartment to the cytosol ; caspase activated Mst-1 and PAK-2 translocate from the cytoplasm to the nucleus
Chan et al., J Cell Biochem 2004 (Carcinoma) : Previously, we showed that PDT stimulates caspase-3 activation and subsequent cleavage and activation of p21 activated kinase 2 (PAK2) in human epidermal carcinoma A431 cells ... We report that curcumin prevented PDT induced JNK activation, mitochondrial release of cytochrome c, caspase-3 activation , and cleavage of PAK2
Koeppel et al., J Biol Chem 2004 : Identification and characterization of PS-GAP as a novel regulator of caspase activated PAK-2 ... Activation of full-length PAK-2 by Rac or Cdc42 stimulates cell survival and protects cells from cell death, whereas caspase activated PAK-2p34 induces a cell death response ... Although many proteins have been shown to interact with and regulate full-length PAK-2, little is known about the regulation of caspase activated PAK-2p34 ... Here, we identify PS-GAP as a regulator of caspase activated PAK-2p34 ... PS-GAP interacts specifically with caspase activated PAK-2p34 , but not active or inactive full-length PAK-2, through a region between the GAP and SH3 domains
Vilas et al., Proc Natl Acad Sci U S A 2006 : Posttranslational myristoylation of caspase activated p21 activated protein kinase 2 (PAK2) potentiates late apoptotic events
Chan et al., Food Chem Toxicol 2006 (Necrosis) : Here, we demonstrate that curcumin can induce apoptotic changes, including JNK activation, caspase-3 activation , and cleavage of PARP and PAK2 , at treatment concentrations lower than 25 microM in human osteoblast cells
Huang et al., Environ Toxicol 2009 : Early-stage JNK activation is solely ROS dependent, whereas late-stage activation is dependent on ROS mediated caspase activity, and regulated by caspase induced activation of PAK2
Hsuuw et al., Ann N Y Acad Sci 2009 : Experiments using caspase-3 inhibitors and antisense oligonucleotides against PAK2 showed that caspase-3 activation is required for PAK2 activation and both of these activations are required for GKB induced apoptosis in ESC-B5 cells
Marlin et al., Mamm Genome 2011 : Functional PAK-2 knockout and replacement with a caspase cleavage-deficient mutant in mice reveals differential requirements of full-length PAK-2 and caspase activated PAK-2p34 ... Activation of full-length PAK-2 by the monomeric GTPases Cdc42 or Rac stimulates cell survival, whereas caspase activation of PAK-2 to the PAK-2p34 fragment is involved in the apoptotic response ... In this study we use functional knockout of PAK-2 and gene replacement with the caspase cleavage-deficient PAK-2D212N mutant to differentiate the biological functions of full-length PAK-2 and caspase activated PAK-2p34 ... However, deficiency of caspase activation of PAK-2 decreased spontaneous cell death of primary mouse embryonic fibroblasts and increased cell growth at high cell density ... In contrast, stress induced cell death by treatment with the anti-cancer drug cisplatin was not reduced by deficiency of caspase activation of PAK-2 , but switched from an apoptotic to a nonapoptotic, caspase independent mechanism ... Homozygous PAK-2D212N primary mouse embryonic fibroblasts that lack the ability to generate the proapoptotic PAK-2p34 show less activation of the effector caspase 3, 6, and 7, indicating that caspase activation of PAK-2 amplifies the apoptotic response through a positive feedback loop resulting in more activation of effector caspases
Rudel et al., Science 1997 : Membrane and morphological changes in apoptotic cells regulated by caspase mediated activation of PAK2 ... Apoptosis of Jurkat T cells induced the caspase mediated proteolytic cleavage of p21 activated kinase 2 (PAK2)