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CXCL2 — KDR

Text-mined interactions from Literome

Petreaca et al., Mol Biol Cell 2007 : IL-8/CXCL8 stimulates VEGFR2 phosphorylation in a VEGF independent manner, suggesting VEGFR2 transactivation ... An inhibitor of Src kinases blocked IL-8/CXCL8 induced VEGFR2 phosphorylation, receptor complex formation, and endothelial permeability
Martin et al., J Biol Chem 2009 : CXCL8/IL8 stimulates vascular endothelial growth factor ( VEGF ) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM ( Carma3/Bcl10/Malt1 ) complex ... Here, we found that CXCL8/IL8 , a potent proangiogenic and inflammatory chemokine, up-regulates VEGF mRNA and protein levels in endothelial cells by acting on its cognate receptor, CXCR2, and that this results in the autocrine activation of VEGFR2