Hurley et al., J Bone Miner Res 1999
:
PTH also increased FGF-2 mRNA, and FGFR-1 and FGFR-2 mRNA levels within 30 minutes in neonatal mouse calvarial organ cultures ... PTH also regulated FGFR gene expression ... We hypothesize that some effects of PTH on bone remodeling may be mediated by regulation of FGF-2 and FGFR expression in osteoblastic cells
Sabbieti et al., J Cell Physiol 2009
:
Parathyroid hormone (PTH) increases fibroblast growth factor receptor-1 ( FGFR1 ) and fibroblast growth factor-2 (FGF-2) expression in osteoblasts and the anabolic response to PTH is reduced in Fgf2-/- mice
Kumata et al., Am J Nephrol 2010
(Hyperparathyroidism, Secondary) :
Thus, both alpha-Klotho and FGFR may play roles in PTH synthesis and/or secretion