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Shinohara et al., Nat Immunol 2006
:
Shortly after TLR9 engagement, colocalization of Opn-i and the adaptor molecule MyD88 was associated with induction of transcription factor IRF7 dependent IFN-alpha gene expression, whereas deficient expression of Opn-i was associated with defective nuclear translocation of IRF7 in pDCs
Watanabe et al., J Clin Invest 2010
(Helicobacter Infections) :
IRF7 induced IFN-beta production, which led to activation of a heterotrimeric transcription factor complex known as IFN stimulated gene factor 3 ( ISGF3 ) and the subsequent production of CXCL10 and additional type I IFN