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CSF2 — TLR4

Text-mined interactions from Literome

Bozinovski et al., Am J Physiol Lung Cell Mol Physiol 2004 (Pneumonia) : Here we report for the first time that the physiological expression of Toll-like receptor-4 in lung is reduced by anti-GM-CSF
Krutzik et al., Nat Med 2005 (Leprosy) : CD1b+ dendritic cells were expanded by TLR mediated upregulation of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and its receptor, promoted T cell activation and secreted proinflammatory cytokines
Berclaz et al., Am J Respir Cell Mol Biol 2007 : Because granulocyte macrophage colony stimulating factor ( GM-CSF ) -deficient ( GM ( -/- ) ) mice are hyporesponsive to LPS, we evaluated the role of GM-CSF in TLR-4 signaling in AMs
O'Mahony et al., International journal of medical sciences 2008 : Of the cytokines examined, IFN-gamma and GM-CSF caused the greatest effects on TLR expression ... GM-CSF up-regulated expression of TLR2 and TLR4 in neutrophils and TLR2 in monocytes
Brosbøl-Ravnborg et al., Clin Exp Immunol 2009 (Crohn Disease) : In CD patients, TLR induced GM-CSF secretion was impaired by both NOD2 dependent and -independent mechanisms
Hammad et al., Nat Med 2009 (Asthma...) : TLR4 triggering on structural cells caused production of the innate proallergic cytokines thymic stromal lymphopoietin, granulocyte-macrophage colony stimulating factor , interleukin-25 and interleukin-33
Fukuzono et al., Arch Biochem Biophys 2010 : G-CSF and GM-CSF did not affect TLR agonist induced phosphorylation of ERK, p38, JNK, Akt, and IkappaBalpha ... These findings suggest that G-CSF and GM-CSF exert the opposite effects on TLR agonist induced cytokine production, and G-CSF negatively regulates TLR agonist induced cytokine production in neutrophils via activation of STAT3
Standiford et al., Am J Physiol Lung Cell Mol Physiol 2012 (Acute Lung Injury...) : TLR4 dependent GM-CSF protects against lung injury in Gram negative bacterial pneumonia
Parajuli et al., Journal of neuroinflammation 2012 : GM-CSF enhanced TLR4 and CD14 expressions in microglia and subsequent LPS binding to the cell surface ... GM-CSF upregulated the levels of p-ERK1/2 and p-p38, suggesting that induction of TLR4 and CD14 expression by GM-CSF was mediated through ERK1/2 and p38, respectively ... These results suggest that GM-CSF upregulates TLR4 and CD14 expression in microglia through ERK1/2 and p38, respectively, and thus promotes the LPS receptor mediated inflammation in the CNS