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Sasaki et al., Brain Res Mol Brain Res 2000 : Expression and role of p27 ( kip1 ) in neuronal differentiation of embryonal carcinoma cells
Zheng et al., Mol Biol Cell 2010 : In this study, we show that Cdk5 phosphorylation of p27 ( Kip1 ) at Thr187 is crucial to neural differentiation because 1 ) neurogenesis is specifically suppressed by transfection of p27 ( Kip1 ) siRNA into Cdk5 ( +/+ ) NSCs ; 2 ) reduced neuronal differentiation in Cdk5 ( -/- ) compared with Cdk5 ( +/+ ) NSCs ; 3 ) Cdk5 ( +/+ ) NSCs, whose differentiation is inhibited by a nonphosphorylatable mutant, p27/Thr187A, are rescued by cotransfection of a phosphorylation mimicking mutant, p27/Thr187D ; and 4 ) transfection of mutant p27 ( Kip1 ) ( p27/187A ) into Cdk5 ( +/+ ) NSCs inhibits differentiation