UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to DEPTOR

DEPTOR — PRR5

Pathways - manually collected, often from reviews:

NCI Pathway Database mTOR signaling pathway: DEPTOR (DEPTOR) → mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5) (modification, collaborate)
Huang et al., Mol Cell Biol 2008, Peterson et al., Cell 2009
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database mTOR signaling pathway: DEPTOR (DEPTOR) → mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5) (modification, collaborate)
Huang et al., Mol Cell Biol 2008, Peterson et al., Cell 2009
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database mTOR signaling pathway: mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5) → mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5) (modification, collaborate)
Huang et al., Mol Cell Biol 2008, Peterson et al., Cell 2009
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database mTOR signaling pathway: mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5) → TSC1/TSC2 complex (TSC1-TSC2) (modification, collaborate)
Huang et al., Mol Cell Biol 2008, Peterson et al., Cell 2009
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database mTOR signaling pathway: RICTOR (RICTOR) → mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5) (modification, collaborate)
Fang et al., Science 2001, Toschi et al., Mol Cell Biol 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database mTOR signaling pathway: RICTOR (RICTOR) → mTOR/GBL/SIN1/PROTOR1/DEPTOR complex (MTOR-MLST8-DEPTOR-MAPKAP1-PRR5) (modification, collaborate)
Fang et al., Science 2001, Toschi et al., Mol Cell Biol 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database mTOR signaling pathway: mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5) → mTOR/GBL/SIN1/PROTOR1/DEPTOR complex (MTOR-MLST8-DEPTOR-MAPKAP1-PRR5) (modification, collaborate)
Fang et al., Science 2001, Toschi et al., Mol Cell Biol 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database mTOR signaling pathway: None → mTOR/GBL/SIN1/PROTOR1/DEPTOR complex (MTOR-MLST8-DEPTOR-MAPKAP1-PRR5) (modification, activates)
Fang et al., Science 2001, Toschi et al., Mol Cell Biol 2009
Evidence: mutant phenotype, physical interaction

Text-mined interactions from Literome

Zhao et al., Mol Cell 2011 : DEPTOR , an inhibitor of mTORC1 and mTORC2 , is degraded via ubiquitin-proteasome pathway by an unknown E3 ubiquitin ligase
Zhao et al., Neoplasia (New York, N.Y.) 2012 (Neoplasms) : Recently, we and others found that DEPTOR , a naturally occurring inhibitor of both mTORC1 and mTORC2 , was degraded by SCF ( Skp1-Cullin-F box proteins ) E3 ubiquitin ligase, the founding member of cullin-RING-ligases ( CRLs ), resulting in mTOR activation and cell proliferation