Gene interactions and pathways from curated databases and text-mining

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CREBBP — PPARD

Pathways - manually collected, often from reviews:

  • BioCarta wnt signaling pathway: beta-catenin/TCF/CtBP1/CBP/TLE1/SMAD4 complex (CTNNB1-TCF1-CTBP1-CREBBP-TLE1-SMAD4) → PPAR-delta (PPARD) (transcription, activates)
  • BioCarta wnt signaling pathway: CtBP1/CBP/TCF/TLE1 complex (CTBP1-CREBBP-TCF1-TLE1) → PPAR-delta (PPARD) (transcription, inhibits)
  • NCI Pathway Database Presenilin action in Notch and Wnt signaling: beta catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 complex (CTNNB1-HNF1A-CTBP1-CREBBP-TLE1-AES) → PPAR delta (PPARD) (transcription, activates)
  • NCI Pathway Database Presenilin action in Notch and Wnt signaling: CtBP/CBP/TCF1/TLE1/AES complex (CTBP1-CREBBP-HNF1A-TLE1-AES) → PPAR delta (PPARD) (transcription, inhibits)

Text-mined interactions from Literome

Berger et al., J Biol Chem 1999 (Diabetes Mellitus, Experimental) : We conclude that : 1 ) synthetic non-thiazolidinediones can serve as ligands of PPARgamma and PPARdelta ; 2 ) ligand dependent activation of PPARdelta involves an apparent conformational change and association of the receptor ligand binding domain with CREB binding protein ; 3 ) PPARgamma activation ( but not PPARdelta or PPARalpha activation ) is sufficient to potentiate preadipocyte differentiation ; 4 ) non-thiazolidinedione PPARgamma agonists improve hyperglycemia and hypertriglyceridemia in vivo ; 5 ) although PPARalpha activation is sufficient to affect triglyceride metabolism, PPARdelta activation does not appear to modulate glucose or triglyceride levels
Sue et al., Am J Physiol Cell Physiol 2009 : Surprisingly, other than altering the CRE binding protein ( CREB ), BPS mediated PPARdelta activation increased nuclear localization of the CREB binding protein (CBP) , a coactivator, which was further confirmed by chromatin immunoprecipitation