We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to HLA-DRB1

HLA-DRB1 — TGFB1

Text-mined interactions from Literome

Pazmany et al., J Neuroimmunol 2000 : Effect of transforming growth factor-beta1 on microglial MHC-class II expression
Delvig et al., J Leukoc Biol 2002 : Consistent with the functional data, TGF-beta1 reduced the constitutive expression of MHC class II transactivator ( CIITA ), MHC class II (MHC-II), invariant chain, and DO mRNA, whereas IFN-gamma up-regulated the expression of CIITA and MHC-II mRNA without affecting invariant chain or DO mRNA
Arai et al., Eur J Immunol 2003 : TGF-beta1-treatment slightly enhanced surface expression of sIgM, but not of MHC class II molecules
Johns et al., Brain Res 1992 (Astrocytoma) : Transforming growth factor-beta 1 differentially regulates proliferation and MHC class-II antigen expression in forebrain and brainstem astrocyte primary cultures ... The disparate responses of brainstem and forebrain astrocytes to transforming growth factor-beta 1 treatment were not limited to effects on cell growth, since transforming growth factor-beta 1 could block interferon-gamma induced MHC class-II antigen expression on cultured brainstem astrocytes but not on forebrain cells
Loughlin et al., Immunology 1993 : In contrast transforming growth factor-beta 1 ( TGF-beta 1 ) causes a reduction in expression of MHC class II on macrophages and of FcR on both cell types
Ljunggren et al., J Reprod Immunol 1998 : TNF-alpha and TGF-beta1 inhibited the IFN-gamma induced MHC class II expression