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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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HNF1A — IL17A

Text-mined interactions from Literome

Yu et al., J Immunol 2011 (Encephalomyelitis, Autoimmune, Experimental) : In this article, we demonstrate that T cell factor-1 (TCF1) negatively regulates the expression of IL-17 and related cytokines in activated CD4 T cells ... Instead, TCF1 regulates IL-17 expression, in part, by binding to the regulatory regions of the Il17 gene
Ma et al., PloS one 2011 (Encephalomyelitis, Autoimmune, Experimental) : Critical role of TCF-1 in repression of the IL-17 gene ... Rag1 ( -/- ) mice reconstituted with TCF-1 ( -/- ) T cells were also susceptible to EAE, indicating TCF-1 is intrinsically required to repress IL-17 ... Furthermore, expression of TCF-1 in TCF-1 ( -/- ) T cells could not restore Th17 differentiation to wild-type levels, indicating that TCF-1 can not affect IL-17 production at the mature T cell stage ... Therefore, TCF-1 mediates an active process to repress IL-17 gene expression via epigenetic modifications during T cell development ... This TCF-1 mediated repression of IL-17 is critical for peripheral T cells to generate balanced immune responses