Gene interactions and pathways from curated databases and text-mining

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ITGA5 — ITGB1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Shibayama et al., Blood 1999 : These data indicate that H-Ras and PLC, but not Raf-1, MAPK kinase, or the MAPK pathway, are involved in the inside-out signaling pathway of IL-3 induced VLA-4 and VLA-5 activation in Baf3 cells
Duncan et al., J Cell Sci 2000 (Cataract) : Overexpression of PAX6 ( 5a ) in lens fiber cells results in cataract and upregulation of ( alpha)5(beta)1 integrin expression
Qiang et al., Exp Hematol 2000 : Activation of mitogen activated protein kinase through alpha5/beta1 integrin is required for cell cycle progression of B progenitor cell line, Reh, on human marrow stromal cells
Casey et al., Clin Exp Metastasis 2000 (Ovarian Neoplasms) : Blocking antibodies against alpha integrin subunits suggest that ovarian carcinoma cell migration toward fibronectin is primarily mediated by the alpha5beta1 integrin , type IV collagen by the alpha2beta1 integrin , and laminin by the alpha6beta1 integrin ... Blocking antibodies against alpha integrin subunits suggest that ovarian carcinoma cell migration toward fibronectin is primarily mediated by the alpha5beta1 integrin , type IV collagen by the alpha2beta1 integrin, and laminin by the alpha6beta1 integrin
Aguirre-Ghiso et al., Mol Biol Cell 2001 : Activation of alpha5beta1-integrin by uPAR generates persistently high level of active ERK necessary for tumor growth in vivo
Lee et al., Biochim Biophys Acta 2002 : The alpha5beta1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase/Akt pathway in intestinal epithelial cells
Zhao et al., J Biol Chem 2002 : An increase in apoE synthesis after plating on fibronectin could be observed by 2 h and was inhibited by blocking antibodies to the alpha(5)beta(1) integrin receptor for fibronectin
Liu et al., Cancer Cell 2002 (Carcinoma, Hepatocellular...) : Urokinase plasminogen activator receptor ( uPAR ) activates alpha5beta1 integrin and ERK signaling, inducing in vivo proliferation of HEp3 human carcinoma
Srinivasan et al., Circ Res 2003 (Diabetes Mellitus, Type 2) : These data indicate that glucose regulates monocyte : endothelial interactions through stimulation of IL-8 and ROS production and activation of the alpha5beta1 integrin complex on HAECs
Wilson et al., Invest Ophthalmol Vis Sci 2003 : Fibronectin fragments promote human retinal endothelial cell adhesion and proliferation and ERK activation through alpha5beta1 integrin and PI 3-kinase
Aguirre-Ghiso et al., Cancer Res 2003 (Breast Neoplasms...) : Mechanistic analysis implicated high uPAR expression and its interaction with and activation of alpha5beta1-integrin as determinants of the in vivo growth promoting high ERK/p38 ratio in several cell lines
Loeser et al., J Biol Chem 2003 : These studies have identified a novel pathway for the MAP kinase regulation of MMP-13 production which involves FN-f stimulation of the alpha5beta1 integrin and activation of the nonreceptor tyrosine kinase PYK2 by PKC, most likely PKCdelta
Wickström et al., J Biol Chem 2003 : Subsequently, through alpha5beta1 integrin , heparan sulfate, and lipid raft mediated interactions, endostatin induced Src dependent activation of p190RhoGAP with concomitant decrease in RhoA activity and disassembly of actin stress fibers and focal adhesions ... Subsequently, through alpha5beta1 integrin , heparan sulfate, and lipid raft mediated interactions, endostatin induced Src dependent activation of p190RhoGAP with concomitant decrease in RhoA activity and disassembly of actin stress fibers and focal adhesions
Chen et al., J Urol 2003 (Carcinoma, Transitional Cell...) : We tested the hypothesis that BCG initiates NF-kappa B signaling as a consequence of cross linking alpha 5 beta 1 integrin receptors present on the tumor cell surface
Mitra et al., J Environ Pathol Toxicol Oncol 2003 (Melanoma, Experimental...) : RESULTS : The zymographic analysis showed that ligation of cell surface alpha5beta1 integrin by alpha5 monoclonal antibody leads to the expression and activation of MMP-2 and MMP-7 in B16F10 melanoma cells ... RESULTS : The zymographic analysis showed that ligation of cell surface alpha5beta1 integrin by alpha5 monoclonal antibody leads to the expression and activation of MMP-2 and MMP-7 in B16F10 melanoma cells ... CONCLUSION : alpha5beta1 integrin induced expression and activation of MMP-2 and -7 indicates the role of tumor cell surface integrin receptor in the modulation of MMPs and, thereby, the invasive property of tumor cells ... CONCLUSION : alpha5beta1 integrin induced expression and activation of MMP-2 and -7 indicates the role of tumor cell surface integrin receptor in the modulation of MMPs and, thereby, the invasive property of tumor cells
Alahari et al., EMBO J 2004 : Nischarin binding to PAK1 is enhanced by active Rac, with the three proteins forming a complex, while expression of the alpha5beta1 integrin also increases the Nischarin/PAK1 association
Disatnik et al., J Cell Sci 2004 : These results demonstrate a direct biochemical pathway linking alpha5beta1 integrin signaling to cytoskeletal dynamics and involving bi-directional translocation of MARCKS during the dramatic changes in cellular morphology that occur during cell migration and tissue morphogenesis
Garciadiego-Cázares et al., Development 2004 : In the presence of BMP7 , inhibition of alpha5beta1 integrin function still induced the formation of the ectopic joint between proliferating chondrocytes and hypertrophic chondrocytes
Lowrie et al., Br J Cancer 2004 (Carcinoma...) : Latent effects of fibronectin, alpha5beta1 integrin , alphaVbeta5 integrin and the cytoskeleton regulate pancreatic carcinoma cell IL-8 secretion
Han et al., Int J Cancer 2005 (Carcinoma, Non-Small-Cell Lung...) : Overall, these findings suggest that COX-2 inhibitors suppress alpha5beta1 integrin expression in NSCLC through effects on integrin alpha5 gene transcription mediated by Erk activation, increased Sp1, decreased AP-1 DNA binding and inactivation of SAPK/JNK signals
Lu et al., Mol Pharmacol 2006 : Laulimalide inhibited integrin activation ; however, compared with docetaxel, it had a weaker inhibitory effect on the VEGF induced association of VEGFR-2 with the alpha5beta1 integrin ... Compared with docetaxel, laulimalide more potently caused a reduction in the constitutive levels ( i.e., in the absence of VEGF ) of phosphorylated paxillin and more potently inhibited the association of RhoA with the alpha5beta1 integrin
Wu et al., J Cancer Res Clin Oncol 2006 (Breast Neoplasms) : In this study we investigated the effects of E-cadherin on cell-matrix adhesion and alpha5beta1 integrin expression in human breast carcinoma cells
Reyes-Reyes et al., Exp Cell Res 2006 (Adenocarcinoma...) : Using a model system of cultured Colo 320 human colon adenocarcinoma cells incubated with soluble P-selectin-IgG chimeric protein, we have found that P-selectin can stimulate activation of the alpha(5)beta(1) integrin resulting in a specific increase of adhesion and spreading of these cells on fibronectin substrates ... These results suggest that P-selectin binding to tumor cells can activate alpha(5)beta(1) integrin via PI3-K and p38 MAPK signaling pathways leading to increased cell adhesion
Camacho-Leal et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : Inhibition of PI3-K and ILK, but not MAPK , prevented the alpha5beta1 integrin activation ... Inhibition of PI3-K and ILK , but not MAPK, prevented the alpha5beta1 integrin activation ... Inhibition of PI3-K and ILK, but not MAPK, prevented the alpha5beta1 integrin activation
Kragtorp et al., Dev Dyn 2007 : Loss of integrin alpha5 delayed somite turning and accumulation of integrin beta1 at somite boundaries, and disrupted the fibronectin matrix surrounding developing somites
Tyagi et al., Mol Cell Biochem 2008 (Cardiovascular Diseases) : In cultured ECs, Fg binding to intercellular adhesion molecule-1 and to alpha(5)beta(1) integrin , caused phosphorylation of ERK
Alsaleh et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid) : BAFF synthesis by rheumatoid synoviocytes is positively controlled by alpha5beta1 integrin stimulation and is negatively regulated by tumor necrosis factor alpha and Toll-like receptor ligands ... In contrast, we demonstrated that stimulation of alpha5beta1 integrin can induce BAFF synthesis and release per se and that stimulation of this pathway has no inhibitory effect on IFNgamma induced BAFF synthesis
Das et al., Life Sci 2008 (Breast Neoplasms) : Blocking of alpha5beta 1 integrin with anti-alpha5 monoclonal antibody inhibits the fibronectin induced MMP activation response appreciably
Reyes-Reyes et al., Exp Cell Res 2008 (Adenocarcinoma...) : We have previously shown that P-selectin binding to Colo-320 human colon carcinoma cells induces specific activation of the alpha(5)beta(1) integrin with a concomitant increase of cell adhesion and spreading on fibronectin substrates in a phosphatidylinositol 3-kinase (PI3-K) and p38 MAPK dependent manner ... We have previously shown that P-selectin binding to Colo-320 human colon carcinoma cells induces specific activation of the alpha(5)beta(1) integrin with a concomitant increase of cell adhesion and spreading on fibronectin substrates in a phosphatidylinositol 3-kinase (PI3-K) and p38 MAPK dependent manner
Bass et al., J Cell Biol 2008 : Matrix induced tyrosine phosphorylation of p190RhoGAP is stimulated solely by engagement of alpha(5)beta(1) integrin and is independent of syndecan-4
Valdembri et al., PLoS Biol 2009 : Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells ... Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells
Yap et al., Oncogene 2009 (Carcinoma, Squamous Cell...) : We found that alphavbeta6- and alpha5beta1-integrin dependent activation of Rac1 was mediated through Eps8
Tuomi et al., Science signaling 2009 (Lung Neoplasms...) : Disruption of intercellular adhesions, increased abundance of alpha(5)beta(1) integrin , and activation of protein kinase Cepsilon ( PKCepsilon ) correlate with invasion and unfavorable prognosis in lung cancer
Yang et al., J Biol Chem 2010 (Ion Channel Gating) : Thus, BK channel activity is enhanced by alpha5beta1 integrin activation, likely through an intracellular signaling pathway involving c-src phosphorylation of the channel alpha-subunit at Tyr-766
Fiedler et al., Haematologica 2012 (Chromosome Deletion...) : All platelets of patients expressed normal levels of CD41/61, CD49b, and CD49f receptors, while CD42a/b and CD29 were slightly reduced and the fibronectin receptor CD49e markedly reduced
Galiano et al., J Clin Invest 1996 (Skin Ulcer) : Our results suggest that activation of both the IGF-I receptor and the alpha5beta1 integrin is required for IGF-I to stimulate wound healing
Magro et al., Gen Diagn Pathol 1997 (Dupuytren Contracture) : These findings suggest that the alpha5beta1 integrin/fibronectin complex may be involved in regulating the interactions between myofibroblasts and ECM in palmar fibromatosis
Xie et al., J Biol Chem 1998 : Our results suggest that TNF-alpha may regulate macrophage differentiation and critical matrix degrading activities of myeloid progenitor cells in an autocrine manner by augmenting surface levels of the alpha5 beta1 integrin , thus promoting interactions with the extracellular matrix, a key event for maturation and migration of these cells during inflammation
Kagami et al., Biochem Biophys Res Commun 1998 : Immunoprecipitation using 35S-metabolic labeling, flow cytometry and a 3H-thymidine-uptake analysis demonstrated that PDGF-BB stimulated the cell mitogenicity and the expression of alpha5beta1 integrin ( a fibronectin receptor ), but not alpha1beta1 integrin ( a collagen and laminin receptor ) of MCs on plastic, in a dose dependent manner ... Thus, the parallel up-regulation of MC-mitogenicity and alpha5beta1 integrin expression by PDGF-BB suggested that alpha5beta1 integrin is an important ECM receptor involved in the proliferative phenotype of MC
Collo et al., J Cell Sci 1999 : We have investigated the effect of wound induced two-dimensional migration, basic fibroblast growth factor (bFGF), transforming growth factor-beta1 ( TGF-beta1 ) and leukemia inhibitory factor (LIF) on expression of the alpha5beta1 integrin in endothelial cells ... We have investigated the effect of wound induced two-dimensional migration, basic fibroblast growth factor (bFGF) , transforming growth factor-beta1 ( TGF-beta1 ) and leukemia inhibitory factor (LIF) on expression of the alpha5beta1 integrin in endothelial cells ... We have investigated the effect of wound induced two-dimensional migration, basic fibroblast growth factor (bFGF), transforming growth factor-beta1 ( TGF-beta1 ) and leukemia inhibitory factor (LIF) on expression of the alpha5beta1 integrin in endothelial cells ... We have investigated the effect of wound induced two-dimensional migration, basic fibroblast growth factor (bFGF), transforming growth factor-beta1 ( TGF-beta1 ) and leukemia inhibitory factor (LIF) on expression of the alpha5beta1 integrin in endothelial cells