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NOS1 — TLR3
Text-mined interactions from Literome
Brightbill et al., Science 1999
:
Several lipoproteins stimulated
TLR dependent transcription of inducible
nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway
Suliman et al., FASEB J 2005
:
In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with
TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ), interleukin 6,
nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2)
Pindado et al., J Immunol 2007
:
TLR3 dependent induction of
nitric oxide synthase in RAW 264.7 macrophage-like cells via a cytosolic phospholipase A2/cyclooxygenase-2 pathway
Masamune et al., J Gastroenterol 2008
:
TLR ligands
induced expression of monocyte chemoattractant protein 1, cytokine induced neutrophil chemoattractant 1 ( a rat homolog of interleukin-8 ), and inducible
nitric oxide synthase , but not proliferation or type I collagen production
Heo et al., Immunol Lett 2008
(Inflammation) :
Additionally,
TLR4 expression was
reduced by
NOS inhibitor