◀ Back to PI3

CDC42 — PI3

Text-mined interactions from Literome

Chen et al., J Biol Chem 2004 (Cryptosporidiosis) : Here, we tested the role of phosphatidylinositol 3-kinase (PI3K) and frabin, a guanine nucleotide exchange factor specific for Cdc42 in the activation of Cdc42 during C. parvum infection of biliary epithelial cells
Jin et al., Neurochem Int 2007 : These results suggest that the NGF induced ruffling requires activation of Rac1 and Cdc42 , but does not require Ras, PI-3k , Akt and GSK-3beta
Bosse et al., Mol Cell Biol 2007 : Moreover, Cdc42 activation was fully independent of PI3-kinase activity, whereas the latter partly depended on Cdc42
Beemiller et al., Mol Biol Cell 2010 : Fcgamma Receptor ( FcR ) -mediated phagocytosis by macrophages requires phosphatidylinositol 3-kinase (PI3K) and activation of the Rho-family GTPases Cdc42 and Rac1
Kim et al., Exp Mol Med 2012 (Diabetes Mellitus, Experimental...) : The phosphoinositide 3-kinase (PI3K) inhibitor, wortmannin, simultaneously regulates Rac1 and Cdc42 , which destabilize the podocyte actin cytoskeleton during early DN
Zheng et al., J Biol Chem 1994 : In addition, PI 3-kinase activity immunoprecipitated from cell lysates with anti-p85 antibody was stimulated 2-4-fold by GST-Cdc42-GTP gamma S. Similar interactions were observed between p85 and GST-Rac1-GTP gamma S but not between p85 and GST-RhoA-GTP gamma S ... These findings suggest that PI 3-kinase , through the Rho-GAP homology domain of p85, can couple to the effector domain of Cdc42Hs and that p85 may be a target for the GTP bound forms of Cdc42Hs and Rac1