◀ Back to PI3

PI3 — SLC9A3

Text-mined interactions from Literome

Donowitz et al., Ann N Y Acad Sci 2000 : PI 3-kinase was also involved in FGF stimulation of NHE3 expressed in fibroblasts
Lee-Kwon et al., J Biol Chem 2001 : Previous studies have indicated that PI 3-kinase is necessary for basal Na(+)/H(+) exchanger 3 ( NHE3 ) transport and for fibroblast growth factor stimulated NHE3 activity in PS120 fibroblasts ... However, it is not known whether activation of PI 3-kinase is sufficient to stimulate NHE3 activity or whether Akt is involved in this PI 3-kinase effect ... We used an adenoviral infection system to test the possibility that activation of PI 3-kinase or Akt alone is sufficient to stimulate NHE3 activity ... The magnitudes of stimulation of NHE3 by constitutively active PI 3-kinase , PI 3-kinase peptide, and constitutively active Akt were similar to each other ... These results demonstrate that activation of PI 3-kinase or Akt is sufficient to stimulate NHE3 transport activity in PS120/NHE3 cells
He et al., Mol Biol Cell 2011 : Activation of SGK3 and NHE3 by Dex was dependent on phosphoinositide 3-kinase (PI3K) and phosphoinositide dependent kinase 1 ( PDK1 ), and Dex induced translocation of PDK1 to endosomes