UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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FN1 — PLAU

Pathways - manually collected, often from reviews:

NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → uPA/uPAR/alpha5/beta1 Integrin/Fibronectin complex (PLAUR-FN1-PLAU-ITGA5-ITGB1) (modification, collaborate)
Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
Evidence: physical interaction
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → Fibronectin complex (FN1) (modification, collaborate) Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
Evidence: physical interaction
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alpha5/beta1 Integrin/Fibronectin complex (PLAUR-FN1-PLAU-ITGA5-ITGB1) → Fibronectin complex (FN1) (modification, collaborate) Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → uPA/uPAR/alpha5/beta1 Integrin/Fibronectin complex (PLAUR-FN1-PLAU-ITGA5-ITGB1) (modification, collaborate)
Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha5/beta1 Integrin complex (PLAUR-PLAU-ITGA5-ITGB1) → Fibronectin complex (FN1) (modification, collaborate) Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: uPA/uPAR/alpha5/beta1 Integrin/Fibronectin complex (PLAUR-FN1-PLAU-ITGA5-ITGB1) → Fibronectin complex (FN1) (modification, collaborate) Simon et al., J Biol Chem 2000, Wei et al., J Cell Biol 2005, Chaurasia et al., J Biol Chem 2006, Wei et al., J Biol Chem 2007
Evidence: physical interaction