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HRAS — PRKCA

Pathways - manually collected, often from reviews:

• KEGG MAPK signaling pathway: PRKCA/PRKCB/PRKCG → HRAS/KRAS/MRAS/NRAS/RRAS/RRAS2 (protein-protein, phosphorylation)
  
• KEGG Pathways in cancer: PRKCA/PRKCB/PRKCG → HRAS/KRAS/NRAS (protein-protein, indirect effect)
• KEGG Glioma: PRKCA/PRKCB/PRKCG → HRAS/KRAS/NRAS (protein-protein, activation)
• KEGG Glioma: PRKCA/PRKCB/PRKCG → HRAS/KRAS/NRAS (protein-protein, activation)
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: PKC alpha (PRKCA) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Dreikhausen et al., Int Immunol 2003, Troppmair et al., Oncogene 1992*
  Evidence: mutant phenotype, other species
• NCI Pathway Database Ras signaling in the CD4+ TCR pathway: PKC alpha (PRKCA) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Dreikhausen et al., Int Immunol 2003, Troppmair et al., Oncogene 1992*
  Evidence: mutant phenotype, other species
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: PKC alpha (PRKCA) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Dreikhausen et al., Int Immunol 2003, Troppmair et al., Oncogene 1992*
  Evidence: mutant phenotype, other species
• NCI Pathway Database Ras signaling in the CD4+ TCR pathway: PKC alpha (PRKCA) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Dreikhausen et al., Int Immunol 2003, Troppmair et al., Oncogene 1992*
  Evidence: mutant phenotype, other species
• NCI Pathway Database Endothelins: HRAS/GDP complex (HRAS) → Typical PKCs (PRKCD/PRKCG/PRKCB/PRKCQ/PRKCB/PRKCA/PRKCE/PRKCH) (modification, collaborate)
  Arai et al., Mol Pharmacol 2003, Yogi et al., Arterioscler Thromb Vasc Biol 2007
  Evidence: mutant phenotype

Text-mined interactions from Literome

Deli et al., Arch Biochem Biophys 2000 : These results suggest that activation of the PtdEtn hydrolyzing PLD enzyme by PKC-alpha is inhibited by p21 Ras
Beaudry et al., Endocrinology 2006 : Inhibition of PKC alpha leads to a decrease in both p21(ras) activity and cell proliferation, which may facilitate AT2 receptor signaling through p42/p44(mapk), thereby leading to neurite outgrowth
Uberall et al., Cell Signal 1994 : Depletion of PKC alpha by bryostatin 1 does not reduce the transcriptional activation of the SRE-FAP-TK-CAT ( TK : thymidine kinase ) construct by Ha-ras
Uberall et al., Adv Enzyme Regul 1994 : Depletion of PKC alpha by bryostatin 1 does not reduce the transcriptional activation of the SRE-FAP-TK-CAT-construct by Ha-ras