Gene interactions and pathways from curated databases and text-mining

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PDGFRA — PRKCA

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: PDGFRA → PRKCA (decreases) Heldin et al., Physiol Rev 1999
    Evidence: Protein kinase C (PKC) seems to be involved in negative regulation of the alpha -receptor, since overexpression of PKC-alpha suppressed the expression of the alpha -receptor but not the beta -receptor (125).
  • OpenBEL Selventa BEL large corpus: PDGFRA → PRKCA (decreases, PDGFRA Activity) Heldin et al., Physiol Rev 1999
    Evidence: Protein kinase C (PKC) seems to be involved in negative regulation of the alpha -receptor, since overexpression of PKC-alpha suppressed the expression of the alpha -receptor but not the beta -receptor (125).