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SMAD5 — SMAD6

Pathways - manually collected, often from reviews:

• BioCarta alk in cardiac myocytes: SMAD6 → SMAD (SMAD4/SMAD5/SMAD1/SMAD6) (modification, activates)
  
• KEGG TGF-beta signaling pathway: SMAD6/SMAD7 → SMAD1/SMAD5/SMAD9 (protein-protein, inhibition)
• NCI Pathway Database BMP receptor signaling: SMAD5 (SMAD5) → SMAD6/SMURF1/SMAD5 complex (SMAD6-SMURF1-SMAD5) (modification, collaborate)
  Zhu et al., Nature 1999, Murakami et al., Mol Biol Cell 2003
  Evidence: physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD5 (SMAD5) → SMAD6/SMURF1 complex (SMAD6-SMURF1) (modification, collaborate)
  Zhu et al., Nature 1999, Murakami et al., Mol Biol Cell 2003
  Evidence: physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD6/SMURF1/SMAD5 complex (SMAD6-SMURF1-SMAD5) → SMAD6/SMURF1 complex (SMAD6-SMURF1) (modification, collaborate)
  Zhu et al., Nature 1999, Murakami et al., Mol Biol Cell 2003
  Evidence: physical interaction
• Reactome Reaction: SMAD5 → SMAD6 (direct_complex) Hata et al., Genes Dev 1998
• Reactome Reaction: SMAD5 → SMAD6 (reaction) Hata et al., Genes Dev 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SMAD5 — SMAD6 (physical association, affinity chromatography technology) Murakami et al., Mol Biol Cell 2003
• Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999

Text-mined interactions from Literome

Ishisaki et al., J Biol Chem 1999 : Smad6 and Smad7 prevent ligand induced activation of signal transducing Smad proteins in the transforming growth factor-beta family
Ishida et al., J Biol Chem 2000 : These results indicate that the expression of Smad6 is regulated by the effects of BMP activated Smad1/5 on the Smad6 promoter
Zuzarte-Luís et al., Dev Biol 2004 (MAP Kinase Signaling System) : Activation of Smad signaling involves the receptor regulated genes Smad1 and -8, and the inhibitory Smad6 , and results in both the upregulation of gene transcription and protein phosphorylation with subsequent nuclear translocation
He et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2004 : Transient overexpression of Smad1 or Smad5 was enhanced , while overexpression of Smad6 inhibited BMP-2 induced COL1A2 promoter activity
Shen et al., J Biol Chem 2006 : Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation
Gouttenoire et al., Eur J Cell Biol 2010 : In addition, adenoviral expression of Smad6 , an inhibitor of BMP canonical Smad signaling, did not affect expression of total type II procollagen or the ratio of type IIA and type IIB isoforms in mouse chondrocytes exposed to BMP-2
Ellman et al., Gene 2013 : The synergism results from LfcinB mediated activation of Sp1 and SMAD signaling pathways by ( i ) phosphorylation of SMAD 1/5/8 ; ( ii ) downregulation of SMAD inhibitory factors [ i.e., noggin and SMAD6 ( inhibitory SMAD ) ] ; and ( iii ) upregulation of SMAD4 ( universal co-SMAD )