Corchero et al., J Psychopharmacol 2002
:
However, delta9-THC treatment induced PENK gene expression to the same extent in both hypothalamic nuclei of intact, castrated and DHT replaced males
Tomasiewicz et al., Biol Psychiatry 2012
(Disease Susceptibility...) :
These data establish a direct association between THC induced NAcsh Penk upregulation and heroin SA and indicate that epigenetic dysregulation of Penk underlies the long-term effects of THC