Santaniello et al., Tissue Antigens 2006
(Hypertension, Pulmonary...) :
HLA-B35 upregulates the production of endothelin-1 in HLA transfected cells : a possible pathogenetic role in pulmonary hypertension
Lenna et al., J Immunol 2010
(Hypertension, Pulmonary) :
HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells ... Our data demonstrate that HLA-B35 expression at physiological levels via adenoviral vector resulted in significantly increased endothelin-1 (ET-1) and a significantly decreased endothelial NO synthase (eNOS), mRNA, and protein levels