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RAF1 — RELA
Pathways - manually collected, often from reviews:
-
KEGG Tuberculosis:
RAF1
→
NFKB1/RELA
(protein-protein, activation)
Text-mined interactions from Literome
Nakayama et al., Biochem Biophys Res Commun 2003
(MAP Kinase Signaling System) :
Raf1 also
regulates the activation of
NF-kappaB
Fan et al., Oncogene 2007
:
Further studies revealed that
Raf1 positively
regulates the ability of SF to stimulate
NF-kappaB activity and cell protection ... The ability of Raf1 to stimulate
NF-kappaB activity was not
due to the classical
Raf1 -- > MEK1/2 -- > ERK1/2 pathway
Chang et al., Pharmacol Res 2009
:
In this study, we further investigated the
role of
Raf-1 in YC-1 induced
nuclear factor-kappaB (NF-kappaB) activation and COX-2 expression in A549 cells
Burgess et al., CNS Neurol Disord Drug Targets 2010
(Disease Models, Animal...) :
The persistent activation of
cRaf-1 can
activate the proinflammatory factor
NFkappaB and consequently, upregulate the expression of several of its downstream factors such as the amyloid precursor protein (APP), Cox-2 and iNOS
Li et al., EMBO J 1995
:
The same results were obtained in vivo using transfection assays ; 14-3-3 enhanced both
c-Raf-1- and Raf-1 kinase domain
stimulated expression of AP-1- and
NF-kappa B-dependent reporter genes and accelerated Raf-1 kinase domain triggered differentiation of PC12 cells
Folgueira et al., J Virol 1996
:
Because of the similarity between HIV and
Ras-Raf induced
NF-kappa B activation in monocytic cells, we next tested whether HIV induced NF-kappa B activation was mediated by the Ras-Raf signal transduction pathway