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IL1B — MSH5
Text-mined interactions from Literome
Xia et al., J Neuroimmunol 2001
(Bacterial Infections...) :
Gamma ( 2 )
-MSH inhibits LPS induced
IL-1beta gene expression in the brain, pituitary and thymus, and prevents increases in plasma NO levels
Huang et al., Neurosci Lett 2002
(Disease Models, Animal...) :
This study 's objective was to determine whether the anti-inflammatory neuropeptide
alpha-melanocyte stimulating hormone ( MSH ) can
suppress postischemic activation of intracerebral tumor necrosis factor-alpha (TNF-alpha) and
interleukin-1beta (IL-1beta) gene expression
Cui et al., Ophthalmic Res 2005
:
alpha-MSH inhibited
IL-1beta or TNF-alpha stimulated IL-8 and MCP-1 protein levels in the media
Mugridge et al., Eur J Pharmacol 1991
:
Additionally, the
effects of alpha
MSH on the specific binding of
IL-1 beta to B- and T-cells have been investigated to further clarify its inhibitory activities
Metz et al., J Endocrinol 2006
:
In vitro, recombinant carp
IL-1beta stimulates release of
alpha-MSH and N-Ac beta-endorphin from the pituitary gland
Figueiredo et al., Naunyn Schmiedebergs Arch Pharmacol 2013
(Peritonitis) :
NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and
reduced peritoneal macrophage inflammatory protein 2, but not TNF-alpha,
IL-1beta , IL-10, and keratinocyte derived chemokine production
Zelazowski et al., Brain Res 1993
(Disease Susceptibility...) :
The same animal model has been used to investigate the regulatory
effect of alpha
MSH , an immunosuppressive neurohormone, on
IL-1 beta stimulated CRH and AVP secretion
Baumann et al., J Recept Signal Transduct Res 1997
(Melanoma) :
MSH receptors and the
response of human A375 melanoma cells to
interleukin-1 beta
Catania et al., Peptides 1998
(HIV Infections) :
In separate experiments on normal peripheral blood mononuclear cells ( PBMC ),
alpha-MSH ( 1-13 )
inhibited production of
IL-1 beta and TNF alpha induced by HIV envelope glycoprotein gp 120