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IL18 — TCF12
Text-mined interactions from Literome
McDermott et al., Trends Mol Med 2002
(Familial Mediterranean Fever...) :
Disorders of
interleukin-1 processing and of
regulation of nuclear factor kappaB
transcription factor , and possibly defective apoptosis, might be involved in the pathogenesis of all but one of these disorders
Bachmann et al., Mol Cancer Ther 2007
(Leukemia, Myeloid, Acute) :
Because T-box expressed in T cells ( T-bet ) is considered to be of paramount importance for dendritic cell function, the
effects of
IL-18 on this
transcription factor have been investigated in the current study
Sheikh et al., Hepatology 2008
(Hepatitis C...) :
This
transcription factor plays a key role in the expression of cytokines, tumor necrosis factor alpha (TNF-alpha),
interleukin 6, interleukin 8, tumor growth factor beta, and Fas ligand
Chen et al., Immunity 2008
(Arthritis, Rheumatoid...) :
IRF-4 binding protein
inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4
transcription factor
Saraiva et al., Immunity 2009
:
Interleukin-10 production by Th1 cells requires
interleukin-12 induced STAT4
transcription factor and ERK MAP kinase activation by high antigen dose
Reddy et al., J Cell Physiol 2011
(Hyperplasia) :
In addition to inducing its own expression via phosphatidylinositol 3-kinase/Akt dependent IKK/NF-?B activation,
IL-18 stimulated glycogen synthase kinase 3ß phosphorylation and degradation, ß-catenin nuclear translocation and stabilization, T-cell factor-lymphoid enhancer binding factor (
TCF-LEF ) activation, and WISP1 induction
Sung et al., J Biol Chem 1993
:
Stimulation of
interleukin-1 gene transcription may be
caused by the stimulation of
transcription factor activities, including those of AP-1, by these protein phosphatase inhibitors