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CCND1 — PAK1

Text-mined interactions from Literome

Cai et al., Cancer Res 2003 (Breast Neoplasms...) : Such cyclin D1 promoter activation was inhibited by dominant negative forms of Rac1 and PAK1 ... Overexpression of the PAK1 autoinhibitory domain ( residues 83-149 ) but not an inactive PAK1 autoinhibitory domain point mutant ( L107F ) also blocked BCAR3 mediated cyclin D1 activation
Nheu et al., Cell cycle (Georgetown, Tex.) 2004 : PAK is essential for RAS induced upregulation of cyclin D1 during the G1 to S transition ... In this report, using two distinct inhibitors specific for PAK1-3 ( CEP-1347 and WR-PAK18 ), we present the first evidence indicating that the PIX/Rac/CDC42 dependent Ser/Thr kinases PAK1-3 , acting downstream of PI-3 kinase and upstream of the Raf/MEK/ERKs kinase cascade, is essential for RAS induced upregulation of cyclin D1 , but not downregulation of p27
Fernandez-Zapico et al., Cancer Cell 2005 (Adenocarcinoma...) : Mechanistically, the effects of Vav1 require its GEF activity and the activation of Rac1, PAK1 , and NF-kappaB and involve cyclin D1 upregulation ... Mechanistically, the effects of Vav1 require its GEF activity and the activation of Rac1, PAK1 , and NF-kappaB and involve cyclin D1 upregulation
Xiao et al., Mol Cell Biol 2005 (Mesothelioma) : Furthermore, PAK1 stimulated cyclin D1 promoter activity was repressed by cotransfection of NF2, and PAK activity was inhibited by expression of merlin ... Collectively, our data indicate that merlin exerts its antiproliferative effect, at least in part, via repression of PAK induced cyclin D1 expression, suggesting a unifying mechanism by which merlin inactivation might contribute to the overgrowth seen in both noninvasive and malignant tumors
He et al., Biochim Biophys Acta 2008 : The PAK1 ( K299A ) mutant also inhibited the stimulation of the expression of c-myc and cyclin D1 , and of cell proliferation and migration, by gastrins