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BMP2 — TAB1

Pathways - manually collected, often from reviews:

• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, activates)
  Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
  Evidence: mutant phenotype, physical interaction

Text-mined interactions from Literome

Kimura et al., J Biol Chem 2000 : We demonstrate that BMP2 induces activation of TGF-beta activated kinase ( TAK1 ) and subsequent phosphorylation of p38 stress activated protein kinase ... Interestingly, this ectopic expression of Smad6 blocks BMP2 induced TAK1 activation and p38 phosphorylation
Yumoto et al., J Biol Chem 2013 (Cleft Palate) : Our studies show that in neural crest derived craniofacial ecto-mesenchymal cells, Tak1 is not only required for TGF-ß- and bone morphogenetic protein induced p38 Mapk activation but also plays a role in agonist induced C-terminal and linker region phosphorylation of the receptor mediated R-Smads
Shibuya et al., EMBO J 1998 : Role of TAK1 and TAB1 in BMP signaling in early Xenopus development ... Role of TAK1 and TAB1 in BMP signaling in early Xenopus development