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CDK4 — MYLIP

Text-mined interactions from Literome

Lal et al., Mol Cell 2009 : In fact, miR-24 regulates expression of E2F2, MYC, AURKB, CCNA2, CDC2, CDK4 , and FEN1 by recognizing seedless but highly complementary sequences
Antonini et al., J Invest Dermatol 2010 : Concomitant downregulation of miR-34a and miR-34c substantially restored cell cycle progression and expression of cyclin D1 and Cdk4
Lu et al., Cancer Res 2011 (Nasopharyngeal Neoplasms) : Mechanistic investigations revealed that miR-26a suppressed the expression of c-myc, the cyclin D3 and E2, and the cyclin dependent kinase CDK4 and CDK6 while enhancing the expression of CDK inhibitors p14(ARF) and p21 ( CIP1 ) in an EZH2 dependent manner
Maki et al., Anticancer Res 2012 (Mesothelioma...) : miR-34b/c inhibited expression of cyclin-D1, cyclin dependent kinase 4/6, B-cell lymphoma-2 (BCL-2) and increased cleaved poly ( ADP-ribose ) polymerase ( cPARP ) and cleaved caspase-3 after irradiation
Furuta et al., PloS one 2013 (Carcinoma, Hepatocellular...) : Among the candidates, we successfully identified CCNE1, CDC25A, CCND3, CDK4 , and BTRC as direct targets for miR-497 and miR-195
Giglio et al., J Cell Physiol 2013 : In this report we describe that miR-24 directly targets p27 ( Kip1 ) and p16(Ink4a) in primary keratinocyte and in different cancer derived cell lines promoting their proliferation, suggesting that miR-24 is involved in cyclin dependent kinase inhibitors post-transcriptional regulation and that upregulation of miR-24 may play a role in carcinogenesis