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GRB10 — IRS1

Pathways - manually collected, often from reviews:

• WikiPathways Insulin Signaling: SHC3/IRS1/IRS2/SHC1/IRS4/SHC2/GAB1 → RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IRS1 — GRB10 (physical association, affinity chromatography technology) Deng et al., J Biol Chem 2003*
• IRef Biogrid Interaction: IRS1 — GRB10 (direct interaction, pull down) Hansen et al., J Biol Chem 1996*

Text-mined interactions from Literome

Mori et al., Mol Cell Endocrinol 2005 : In spite of these differences, both FL-Grb10 and the BPS-SH2 fragment inhibited insulin stimulated phosphorylation of IRS1 , IRS2, Akt/PKB, Shc, ERK1/2, APS, and c-Cbl to a similar extent
Holt et al., Mol Endocrinol 2009 : These results indicate that, in addition to their described effects on IRS-1/Akt , Grb10 and Grb14 may regulate whole-body glucose homeostasis by additional mechanisms and highlight these adaptors as potential therapeutic targets for amelioration of the insulin resistance associated with type 2 diabetes