Glinka et al., EMBO Rep 2011
(Wnt Signaling Pathway) :
Gain- and loss-of-function experiments in mammalian cells and Xenopus embryos indicate that LGR4 and LGR5 promote R-spondin mediated Wnt/ß-catenin and Wnt/PCP signalling
Deng et al., J Cell Sci 2013
(Wnt Signaling Pathway) :
Using newly available genome sequences, we showed that norrin is a vertebrate ortholog for insect burs and pburs and stimulates Wnt signaling mediated by LGR4 , but not by LGR5 and 6, in mammalian cells
Qian et al., Development 2013
(Wnt Signaling Pathway) :
Lgr4 mediated Wnt/ß-catenin signaling in peritubular myoid cells is essential for spermatogenesis