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CPOX — IL13

Text-mined interactions from Literome

Moore et al., J Appl Physiol 2001 : In human cultured airway smooth muscle cells, interleukin (IL)-1 beta increases cyclooxygenase (COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Peebles et al., Am J Respir Crit Care Med 2002 (Bronchial Hyperreactivity) : We conclude that in the BALB/c mouse, COX inhibition with either a COX-1 or COX-2 inhibitor during allergen sensitization augments production of IL-13 and increases airway hyperresponsiveness
Saito et al., Int Arch Allergy Immunol 2003 (Fibrosis) : IL-4 and IL-13 stimulate fibroblast proliferation and this effect is at least partly due to suppressed COX gene expressions and subsequently decreased PGE ( 2 ) production
Hashimoto et al., J Immunol 2005 (Hypersensitivity...) : Allergen sensitization and airway challenge alone led to undetectable levels of IL-5 and IL-13 in the lungs of IL-4, IL-4Ralpha, and STAT6 knockout ( KO ) mice, but COX inhibition during the development of allergic inflammation resulted in wild-type levels of IL-5 and IL-13 and heightened airway eosinophilia in each of the three KO mice
Helmersson et al., Free radical research 2005 (Cardiovascular Diseases...) : This study investigated the longitudinal association between serum selenium ( s-Se ) and a golden standard indicator of oxidative stress in vivo ( 8-iso-prostaglandin F2alpha, a major F2-isoprostane ), an indicator of cyclooxygenase (COX) mediated inflammation ( prostaglandin F2alpha ), high sensitive C-reactive protein ( hsCRP ), interleukin-6 (IL-6) and serum amyloid A protein (SAA) in a follow-up study of 27 years
Peebles et al., J Immunol 2005 (Bronchial Hyperreactivity...) : In contrast, the COX inhibition mediated increase in AHR is dependent on IL-13 , but airway eosinophilia is not
Schwartzbaum et al., Cancer Epidemiol Biomarkers Prev 2007 (Genetic Predisposition to Disease...) : In addition, recent studies suggest that IL-4 and IL-13 induce cyclooxygenase-2 (COX-2) to resolve brain inflammation
Zhou et al., J Immunol 2008 (Inflammation...) : COX inhibition during sensitization increased the numbers of mature dendritic cells and activated CD4 T cells in the spleen and augmented OVA-specific IL-5 and IL-13 responses of the splenic CD4 T cells at day 5 after sensitization
Endo et al., Am J Respir Cell Mol Biol 1998 : Lipopolysaccharide (LPS) stimulated PGE2 synthesis and COX activity were suppressed significantly by IL-4, but were not affected significantly by IL-10, IL-13 , or IFN-gamma
Dean et al., J Biol Chem 1999 : We have previously shown that the pyridinyl imidazole SB 203580, which inhibits it, blocks the interleukin-1 induction of cyclooxygenase-2 (COX-2) and matrix metalloproteinase 1 and 3 mRNAs in fibroblasts