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APOB — MMP2
Text-mined interactions from Literome
Ardans et al., J Leukoc Biol 2002
:
ox-LDL,
LDL , and HDL alone
had no effect on MMP-1,
MMP-9 , or TIMP-1 production
Kume et al., Nihon rinsho. Japanese journal of clinical medicine 2004
(Arteriosclerosis) :
Lectin-like oxidized LDL receptor-1 ( LOX-1 ) is a cell surface receptor for oxidized LDL, which is abundantly expressed in atherosclerotic plaques and is involved in oxidized
LDL induced MMP production and apoptosis
Torzewski et al., Arterioscler Thromb Vasc Biol 2004
(Arteriosclerosis) :
E-LDL produced with any protease/CEH combination was efficiently taken up by human macrophages, whereby marked
induction of
MMP-2 expression by
E-LDL was observed
May et al., Thromb Haemost 2005
(Arteriosclerosis) :
We studied the
effect of
E-LDL on the activation of plasminogen and matrix metalloproteinases ( MMPs ) in monocytes and vascular smooth muscle cells ( VSMCs ) as well as on
MMP activation during cellular interactions ... In VSMCs,
E-LDL induced MMP-1 and
MMP-2 secretion ... Together, enzymatical modification of
LDL allows a direct activation of
MMP expression in monocytes and VSMCs, and indirectly promotes the induction of paracrine, cytokine mediated intercellular activation processes