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IFNG — LEP
Text-mined interactions from Literome
Eriksson et al., Clin Exp Allergy 2001
(Hypersensitivity, Immediate) :
The atopic subjects produced significantly lower
IFN-gamma in
response to
Lep d 2.01 as compared to the non-atopics
Raso et al., Br J Pharmacol 2002
:
Here we have studied the
effect of
leptin on expression of
IFN-gamma induced nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2), both prominent markers of macrophage activation, using the murine macrophage J774A.1 cell line
Meier et al., Cytokine 2003
(Obesity) :
Leptin strongly
enhanced the expression and secretion of the
interferon-gamma-inducible protein ( IP-10 ) in a human monocytic cell line, as well as in peripheral blood mononuclear cells
Fantuzzi et al., Clin Exp Immunol 2005
(Colitis...) :
Spontaneous production of IL-6 from colon cultures obtained from recipients of ob/ob cells was reduced compared to recipients of WT cells, whereas stimulation of lamina propria lymphocytes with
leptin resulted in a higher
IFNgamma release in recipients of ob/ob cells compared to recipients of WT cells
Simons et al., Cytokine 2005
:
IFN-gamma also strongly
reduced leptin production ( > or =85 % )
Chen et al., Neuroscience bulletin 2006
:
Results Our data showed that
leptin induced IFN-gamma production by PBMCs of patients in an acute phase of disease but not in a stable phase or in healthy controls