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IFNG — NFATC2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3)
→
IFN-gamma (IFNG)
(transcription, activates)
Curtsinger et al., J Exp Med 2003, Curtsinger et al., J Immunol 2005, Teixeira et al., J Immunol 2005, Campbell et al., Transplantation 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes:
NFAT1 (NFATC2)
→
IFN-gamma (IFNG)
(transcription, activates)
Agarwal et al., Immunity 2000*, Avni et al., Nat Immunol 2002*, Lee et al., J Biol Chem 2004*
Evidence: reporter gene, physical interaction, other species
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3)
→
IFN-gamma (IFNG)
(transcription, activates)
Curtsinger et al., J Immunol 2005, Campbell et al., Transplantation 1996
Evidence: mutant phenotype, physical interaction, other species
Text-mined interactions from Literome
Kadereit et al., J Clin Immunol 2003
:
Here we show that
NFATc2 expression in T cells is
dependent in part on the presence of
IFN-gamma during primary stimulation, as blocking of IFN-gamma blunted NFATc2 protein and mRNA upregulation
Karwot et al., J Allergy Clin Immunol 2008
(Bronchial Hyperreactivity...) :
Taken together, our results suggest that
NFATc2 expression in long lived memory CD8+ T cells
controls IL-2 and
IFN-gamma production in lung CD8+ T cells, which then limits TH17 and TH2 development in the airways during allergen challenge