We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to IGF1

IGF1 — SPAG8

Text-mined interactions from Literome

Tomlinson et al., Endocr Res 2000 (Obesity...) : IGF-1 caused a dose dependant inhibition of 11beta-HSD1 activity in both subcutaneous and omental stromal cells
Stewart et al., Horm Res 2001 (Hypopituitarism...) : These clinical data suggest that GH ( and/or IGF-I ) inhibits 11beta-HSD1 ( i.e. E to F conversion ) ( parallel in vitro studies suggest that IGF-I and not GH inhibits 11beta-HSD1 )
Patel et al., Development 2008 : Finally, we found that the HSD-1 mediated signal activates insulin/IGF-I signaling in a cell non-autonomous fashion, suggesting a novel mechanism for how these two endocrine pathways intersect in directing development
Morita et al., Endocr J 2009 : In the present study, we investigated the effects of GH or IGF-I on the activity of 11beta- HSD1 in 3T3-L1 cell homogenates and its mRNA expression