◀ Back to PTEN

PTEN — TGFB1

Text-mined interactions from Literome

Ebert et al., Br J Cancer 2002 (Pancreatic Neoplasms) : Recently, it has been demonstrated that PTEN expression is regulated by TGF-beta1 ... In addition, in the pancreas of TGF-beta1 transgenic mice the expression of PTEN was significantly reduced ( P < 0.01 ), as compared to wildtype littermates and incubation of PANC-1 cells with TGF-beta1 decreased PTEN mRNA levels after 24 h. Inasmuch as TGF-beta1 decreases PTEN expression in human pancreatic cancer cells and human pancreatic cancers overexpress TGF-beta1, the reduced expression of PTEN in pancreatic cancer may be mediated by TGF-beta1 overexpression
Chow et al., Carcinogenesis 2007 (Pancreatic Neoplasms) : Phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) is rarely mutated in pancreatic cancers, but its regulation by transforming growth factor ( TGF ) -beta might mediate growth suppression and other oncogenic actions
Yang et al., J Cell Biochem 2009 (Carcinoma, Hepatocellular...) : Previous studies have showed that PTEN mRNA expression is down-regulated by TGF-beta1 in various cell lines ... Based on the PTEN promoter dual-luciferase report assay, we have found that PTEN transcription is not affected by TGF-beta1 ... What interested us was that transfection of PTEN coding sequence increased TGF-beta1 induced degradation of PTEN mRNA, suggesting that PTEN coding region was account for TGF-beta1 mediated down-regulation of PTEN ... In addition, TGF-beta1 down-regulated PTEN expression was blocked by the TbetaIR inhibitor SB431542 and the p38 inhibitor SB203580, suggesting Smad and p38 MAPK signal pathways played crucial roles in PTEN down-regulation via TGF-beta1 stimulation ... Collectively, our data clearly demonstrated that TGF-beta1 mediated down-regulation of PTEN was post-transcriptional and post-translational, depending on its coding sequence, Smad and p38-MAPK signal pathways were involved in this down-regulation