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RAC1 — RHOG
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Katoh et al., Nature 2003
:
RhoG activates Rac1 by direct interaction with the Dock180 binding protein Elmo ... The small GTPase RhoG mediates several cellular morphological processes, such as neurite outgrowth in neuronal cells, through a signalling cascade that activates Rac1 ( refs 7-12 ) ; however, the downstream target of RhoG and the mechanism by which
RhoG regulates Rac1 activity remain unclear
Aspenström et al., Biochem J 2004
:
Cdc42, TCL ( TC10-like ), Rac1-Rac3 and
RhoG induced the formation of lamellipodia, whereas Cdc42,
Rac1 and Rac2 also induced the formation of thick bundles of actin filaments
Katoh et al., J Cell Sci 2006
:
Activation of
Rac1 by
RhoG regulates cell migration ... The small GTPase
RhoG activates Rac through its effector ELMO and the ELMO binding protein Dock180, which functions as a Rac-specific guanine nucleotide exchange factor ... Taken together, these results suggest that
RhoG contributes to the regulation of
Rac activity in migrating cells
Yamaki et al., Exp Cell Res 2007
:
Previous studies have shown that
RhoG activates Rac1 and induces several cellular functions including promotion of cell migration through its effector ELMO and the ELMO binding protein Dock180 that function as a Rac-specific guanine nucleotide exchange factor