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MAPK1 — TRH

Text-mined interactions from Literome

Coya et al., J Neuroendocrinol 1999 : The short-term TGF-beta1 effect did not modify Erk-2 phosphorylation, basal or TRH induced increase in intracellular calcium concentration, but blunted basal and forskolin stimulated cAMP levels
Kanasaki et al., Biol Reprod 1999 (Pituitary Neoplasms...) : We examined whether mitogen activated protein ( MAP ) kinase is activated by thyrotropin releasing hormone (TRH) in GH3 cells, and whether MAP kinase activation is involved in secretion of prolactin from these cells
Wang et al., Mol Endocrinol 1999 (Pituitary Neoplasms) : Treatment with the MAPKK inhibitor, PD98059, blocked TRH induced activation of MAPK and also reduced TRH induction of a PRL-luciferase reporter gene, confirming that MAPK activation is necessary for TRH effects on PRL gene expression ... A PKC inhibitor, GF109203X, and an L-type Ca2+ channel blocker, nimodipine, both partially reduced TRH induced MAPK activation and PRL promoter activity
Wang et al., Mol Endocrinol 2000 (Pituitary Neoplasms) : EGF receptor phosphorylation was required for full TRH induced activation of mitogen activated protein kinase ( MAPK ) and stimulation of specific transcriptional responses
Banihashemi et al., Mol Endocrinol 2002 : Activation of the dopamine-D2S receptor inhibited forskolin induced cAMP production, reduced BayK8644- activated calcium influx, and blocked TRH mediated p42/p44 MAPK phosphorylation ... D2S stimulation also decreased TRH induced MAPK/ERK kinase phosphorylation
Nafisi et al., J Biol Chem 2008 : The dopamine D2S receptor ( short isoform ) couples to inhibitory Galphai/o proteins to inhibit thyrotropin releasing hormone (TRH) stimulated p42/p44 mitogen activated protein kinase ( ERK1/2 ) phosphorylation in GH4ZR7 rat pituitary cells, consistent with its actions to inhibit prolactin gene transcription and cell proliferation
Ohmichi et al., J Biol Chem 1994 (Pituitary Neoplasms) : Regulation of the mitogen activated protein ( MAP ) kinase by thyrotropin releasing hormone (TRH) in GH3 rat pituitary tumor cells was investigated
Ohmichi et al., Biochem Biophys Res Commun 1994 : We recently reported the existence of two separate pathways for thyrotropin releasing hormone (TRH) induced mitogen activated protein ( MAP ) kinase activation in GH3 pituitary tumor cells
Palomero et al., Mol Pharmacol 1998 : A G protein beta gamma dimer mediated pathway contributes to mitogen activated protein kinase activation by thyrotropin releasing hormone receptors in transfected COS-7 cells ... Long term treatment of the cells with pertussis toxin has no effect on TRH induced MAPK activation ... In contrast, only approximately 50 % of the TRH induced MAPK activity is inhibited by GF109203X, indicating that activation of MAPK by TRH is only partially dependent on PKC ... The TRH induced activation of MAPK also is inhibited partially by overexpression of transducin alpha subunits ( alpha t ), an agent known to sequester free G protein beta gamma dimers ... Our results demonstrate that TRH receptors activate MAPK by a pathway only partially dependent on PKC activity