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CASP3 — LPA

Text-mined interactions from Literome

Deng et al., Gastroenterology 2002 : LPA inhibited the activation of caspase-3/CPP32 and attenuated its activity
Campbell et al., Neuron 2003 : In addition, we report that caspase-3 , an apoptotic protease, is rapidly activated by netrin-1 and LPA in a proteasome- and p38 dependent manner and is required for chemotropic responses
Deng et al., Am J Physiol Gastrointest Liver Physiol 2003 : LPA reduced cytochrome c release from mitochondria and prevented activation of caspase-9
Meng et al., Gynecol Oncol 2005 (Neoplasm Invasiveness...) : DISC staining proved that LPA inhibited Fas receptor aggregation and caspase-8 activation at the membrane, which further inhibited caspase-3 and 7 activation in the cytosol
Meng et al., FEBS Lett 2005 (Ovarian Neoplasms) : Immunoprecipition of Fas death inducing signaling complex ( DISC ) and Western blot suggested that the actin depolymerization accelerated caspase-8 activation, while LPA inhibited the association and activation of caspase-8 at the DISC ... LPA inhibited caspase-3 and 7 activation induced by anti-Fas and/or Cyto D in cytosols