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EFNA1 — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database EPHA2 forward signaling: RAC1/GTP complex (RAC1) → Ephrin A1/EPHA2 complex (EFNA1-EPHA2) (modification, collaborate)
  Deroanne et al., J Cell Sci 2003*
  Evidence: assay, other species
• NCI Pathway Database EPHA2 forward signaling: RAC1/GDP complex (RAC1) → Ephrin A1/EPHA2/Tiam1 complex (EFNA1-EPHA2-TIAM1) (modification, collaborate)
  Tanaka et al., EMBO J 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database EPHA2 forward signaling: RAC1/GTP complex (RAC1) → Ephrin A1/EPHA2 complex (EFNA1-EPHA2) (endocytosis, activates)
  Zhuang et al., J Biol Chem 2007*
  Evidence: mutant phenotype, assay
• NCI Pathway Database EPHA2 forward signaling: RAC1/GDP complex (RAC1) → Ephrin A1/EPHA2/VAV2-VAV3 complex (EFNA1-EPHA2-VAV2_VAV3) (modification, collaborate)
  Hunter et al., Mol Cell Biol 2006, Fang et al., J Biol Chem 2008
  Evidence: mutant phenotype, assay
• Reactome Reaction: EFNA1 → RAC1 (reaction) Marston et al., Nat Cell Biol 2003, Yoo et al., Mol Cells 2010
• Reactome Reaction: EFNA1 → RAC1 (indirect_complex) Marston et al., Nat Cell Biol 2003

Text-mined interactions from Literome

Miao et al., J Cell Biol 2003 : Ephrin-A1 suppressed HGF induced activation of Rac1 and p21 activated kinase, whereas RhoA activation was retained, leading to the preservation of stress fibers
Brantley-Sieders et al., J Cell Sci 2004 (Neovascularization, Pathologic) : Ephrin-A1 stimulation induces PI3-kinase dependent activation of Rac1 in wild-type endothelial cells, whereas EphA2-deficient cells fail to activate Rac1 upon stimulation
Hunter et al., Mol Cell Biol 2006 : Overexpression of either Vav2 or Vav3 in primary microvascular endothelial cells promotes Rac1 activation, cell migration, and assembly in response to ephrin-A1 stimulation ... Conversely, loss of Vav2 and Vav3 GEFs inhibits Rac1 activation and ephrin-A1 induced angiogenic responses both in vitro and in vivo
Zhuang et al., J Biol Chem 2007 : Ephrin-A1 stimulation activates Rac1 GTPase, and the Rac1-GTP levels are further increased in SHIP2 knockdown cells
Buricchi et al., Cell Adh Migr 2007 : We identify redox circuitry in which the ephrinA1 mediated inhibition of Rac1 leads to a negative regulation of integrin redox signaling affecting the activity of the tyrosine phosphatase LMW-PTP
Takeuchi et al., FEBS Lett 2009 : We found that the RacGAP beta2-chimaerin ( chimerin ) bound to EphA2 and EphA4 and inactivated Rac1 in response to ephrinA1 stimulation